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However, MPA population pharmacokinetic data in the paediatric population have not been systematically summarized. The objective of this narrative review was to provide an up\u2010to\u2010date critique of currently available paediatric MPA population pharmacokinetic models, with emphases on modelling techniques, pharmacological findings and clinical relevance. PubMed and EMBASE were searched from inception of database to May 2020, where a total of 11 studies have been identified representing kidney transplant (<jats:italic>n<\/jats:italic> = 4), liver transplant (<jats:italic>n<\/jats:italic> = 1), haematopoietic stem cell transplant (<jats:italic>n<\/jats:italic> = 1), idiopathic nephrotic syndrome (<jats:italic>n<\/jats:italic> = 2), systemic lupus erythematosus (<jats:italic>n<\/jats:italic> = 2), and a combined population consisted of kidney, liver and haematopoietic stem cell transplant patients (<jats:italic>n<\/jats:italic> = 1). Critical analyses were provided in the context of MPA absorption, distribution, metabolism, excretion and bioavailability in this paediatric database. Comparisons to adult patients were also provided. With respect to clinical utility, Bayesian estimation models (<jats:italic>n<\/jats:italic> = 6) with acceptable accuracy and precision for MPA exposure determination have also been identified and systematically evaluated. Overall, our analyses have identified unique features of MPA clinical pharmacology in the paediatric population, while recognizing several gaps that still warrant further investigations. 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