{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:24:13Z","timestamp":1791829453839,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","award":["AS\u2010PG\u20102013\u2010017"],"award-info":[{"award-number":["AS\u2010PG\u20102013\u2010017"]}],"id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001592","name":"Higher Education Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To estimate the association between patterns of anticholinergic, benzodiazepine and Z\u2010drug medication use and change in cognitive function in middle\u2010aged and older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective cohort study used data from the first three waves of The Irish Longitudinal Study on Ageing (TILDA), including community\u2010dwelling adults aged \u226550\u00a0years followed for up to 4\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07027). Cognitive function was assessed using the Mini Mental State Examination, animal naming test and word recall tests. Regular medication use was self\u2010reported at baseline and follow\u2010up interviews at 2 and 4\u00a0years. Pharmacy dispensing claims for a subset (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02905) allowed assessment of medication use between interviews and cumulative dosage. Medication use at consecutive waves of TILDA was analysed in relation to change in cognitive function between waves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Strongly anticholinergic medications (Anticholinergic Cognitive Burden scale 3), benzodiazepines and Z\u2010drugs were reported by 7.3%, 5.8% and 5.1% of participants, respectively, at any time during the study. Adjusting for potential confounders, new anticholinergic use between interviews was associated with change in recall score (\u22121.09, 95% confidence interval \u22121.64, \u22120.53) over 2\u00a0years compared to non\u2010use, but not with MMSE (0.07; 95% CI \u22120.21, 0.34) or animal naming (\u22120.70; 95% CI \u22121.43, 0.03). The pharmacy claims analysis was consistent with this finding. Other hypothesised associations were not supported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Except for new use of anticholinergic medications, no other findings supported a risk of cognitive decline over 2\u2010year periods in this middle\u2010aged and older cohort. Patients and prescribers should weigh this potential risk against potential benefits of commencing anticholinergic medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.14687","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T09:34:11Z","timestamp":1606988051000},"page":"2818-2829","source":"Crossref","is-referenced-by-count":29,"title":["Cognitive decline associated with anticholinergics, benzodiazepines and Z\u2010drugs: Findings from The Irish Longitudinal Study on Ageing (TILDA)"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-3625","authenticated-orcid":false,"given":"Frank","family":"Moriarty","sequence":"first","affiliation":[{"name":"HRB Centre for Primary Care Research, Department of General Practice Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"The Irish Longitudinal Study on Ageing Trinity College Dublin Dublin 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