{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:29:37Z","timestamp":1764275377239,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Kisangani is an area with intense malaria transmission and sulfadoxine\u2013pyrimethamine resistance. Alternative antimalaria prophylaxis medication and protocols are needed, particularly with pregnant individuals. In this study, we compare the tolerance and effectiveness of mefloquine regimen as a split dose with a meal <jats:italic>vs<\/jats:italic>. sulfadoxine\u2013pyrimethamine for the intermittent preventive treatment in pregnant individuals in Kisangani.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted from 15 May to 30 November 2019 as a single\u2010blind, randomized clinical trial comparing 2 regimens of intermittent preventive treatment during pregnancy. The first regimen consisted of 4 doses of sulfadoxine\u2013pyrimethamine, and the second of 2 doses of mefloquine taken as a split dose with meal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The occurrence of major or minor side\u2010effects among patients treated with mefloquine and those treated with sulfadoxine\u2013pyrimethamine were not statistically significant (major side effects: Fisher exact = 0.5014; minor side effects: <jats:italic>P<\/jats:italic> = .0961). Intermittent preventive treatment using mefloquine significantly reduced the risk of placental malaria (risk ratio [RR]: 0.4315, 95% confidence interval [CI]: 0.2201\u20130.8460), maternal peripheral parasitaemia (RR: 0.4397, 95% CI: 0.2377\u20130.8132) and low birth weight (RR: 0.4708, 95% CI: 0.2455\u20130.9029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Splitting dose and intake with a meal increased mefloquine tolerability while keeping its efficacy higher compared to sulfadoxine\u2013pyrimethamine. Intermittent preventive treatment during pregnancy using mefloquine reduces the risk of placental malaria, maternal peripheral parasitaemia and low birth weight, compared to sulfadoxine\u2013pyrimethamine. Thus, mefloquine is a good alternative to intermittent preventive treatment in pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14720","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T04:12:44Z","timestamp":1609819964000},"page":"3115-3126","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of malarial prophylaxis with mefloquine during pregnancy in Kisangani, Democratic Republic of Congo: A randomized clinical trial"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-7740","authenticated-orcid":false,"given":"No\u00ebl","family":"Labama Otuli","sequence":"first","affiliation":[{"name":"Department of Gynaecology\u2010Obstetrics, Faculty of Medicine and Pharmacy Kisangani University  Kisangani 2012 Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-5725","authenticated-orcid":false,"given":"Roland","family":"Marini Djang'eing'a","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy Kisangani University  Kisangani Democratic Republic of Congo 2012 Democratic Republic of Congo"},{"name":"Laboratory of Analytical Pharmaceutical Chemistry, CIRM, Department of Pharmacy University of Liege  Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-4488","authenticated-orcid":false,"given":"Joris","family":"Losimba Likwela","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine and Pharmacy Kisangani University  Kisangani Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-5577","authenticated-orcid":false,"given":"Jean\u2010Didier","family":"Bosenge Nguma","sequence":"additional","affiliation":[{"name":"Department of Gynaecology\u2010Obstetrics, Faculty of Medicine and Pharmacy Kisangani University  Kisangani 2012 Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6396-6783","authenticated-orcid":false,"given":"Mike\u2010Antoine","family":"Maindo Alongo","sequence":"additional","affiliation":[{"name":"Department of Gynaecology\u2010Obstetrics, Faculty of Medicine and Pharmacy Kisangani University  Kisangani 2012 Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Ahuka Ona Longombe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Pharmacy Kisangani University  Kisangani Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-0878","authenticated-orcid":false,"given":"Bernard","family":"Mbutu Mango","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur des Techniques M\u00e9dicales de Kisangani  Kisangani Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"M.N. Bono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-580X","authenticated-orcid":false,"given":"John","family":"L. Mokili","sequence":"additional","affiliation":[{"name":"Viral Information Institute, Department of Biology San Diego State University  Californie USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-613X","authenticated-orcid":false,"given":"Jean\u2010Pascal","family":"Manga Okenge","sequence":"additional","affiliation":[{"name":"Department of Gynaecology\u2010Obstetrics, Faculty of Medicine and Pharmacy Kisangani University  Kisangani 2012 Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"volume-title":"World Malaria Report 2017","year":"2018","author":"World Health Organization","key":"e_1_2_11_2_1"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"S1","article-title":"In The Concise Guide to PHARMACOLOGY 2019\/20: Antimalarial targets and ligands","volume":"176","author":"Alexander SPH","year":"2019","journal-title":"Br J Pharmacol"},{"volume-title":"World Malaria Report 2018","year":"2019","author":"World Health Organization","key":"e_1_2_11_4_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.4236\/ojog.2018.810089"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1093\/cid\/cir374"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1111\/j.1365-3156.2008.02215.x"},{"issue":"4","key":"e_1_2_11_8_1","first-page":"10","article-title":"Effet du traitement pr\u00e9ventif intermittent (TPI) de la femme enceinte \u00e0 la Sulfadoxine\u2010Pyrim\u00e9thamine (SP) sur le poids de naissance des enfants dans un milieu \u00e0 r\u00e9sistance \u00e9lev\u00e9e du Plasmodium falciparum \u00e0 la SP \u00e0 l'Est de la R\u00e9publique D\u00e9mocratique du Congo (RDC)","volume":"68","author":"Losimba LJ","year":"2010","journal-title":"Rwanda Med J"},{"doi-asserted-by":"publisher","key":"e_1_2_11_9_1","DOI":"10.1186\/1475-2875-8-25"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_1","DOI":"10.4269\/ajtmh.2007.76.608"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_1","DOI":"10.1186\/s12936-017-1831-y"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_1","DOI":"10.1186\/s12936-017-1695-1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.1186\/s12936-017-1886-9"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1186\/1475-2875-10-196"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_1","DOI":"10.1186\/s12936-019-2734-x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_16_1","DOI":"10.1186\/s12936-016-1634-6"},{"doi-asserted-by":"publisher","key":"e_1_2_11_17_1","DOI":"10.1186\/s12936-015-0909-7"},{"doi-asserted-by":"publisher","key":"e_1_2_11_18_1","DOI":"10.1186\/s12936-015-0765-5"},{"doi-asserted-by":"publisher","key":"e_1_2_11_19_1","DOI":"10.1186\/s12936-017-2160-x"},{"issue":"3","key":"e_1_2_11_20_1","first-page":"322","article-title":"Sulfadoxine\u2013pyrimethamine resistance and intermittent preventive treatment during pregnancy: a retrospective analysis of birth weight data in the Democratic Republic of Congo (DRC)","volume":"17","author":"Losimba LJ","year":"2012","journal-title":"Trop Med Int Health"},{"issue":"12","key":"e_1_2_11_21_1","first-page":"168","article-title":"Intermittent Preventive Treatment in Pregnancy with Sulphadoxine\u2010Pyrimethamine Does Not Have Effect on Maternal Hemoglobin at Delivery and Birth Weight in Kisangani, Democratic Republic of Congo","volume":"7","author":"Labama ON","year":"2019","journal-title":"J Biosci Med"},{"doi-asserted-by":"publisher","key":"e_1_2_11_22_1","DOI":"10.1586\/eri.10.36"},{"doi-asserted-by":"publisher","key":"e_1_2_11_23_1","DOI":"10.1086\/605474"},{"issue":"458","key":"e_1_2_11_24_1","article-title":"Efficacy and safety of a combination of Azithromycine and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi\u2010country randomized clinical trials in African adults","volume":"13","author":"Sagara I","year":"2014","journal-title":"Malar J"},{"issue":"11","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001166","article-title":"A Randomized Controlled Pilot Trial of Azithromycin or Artesunate Added to Sulfadoxine\u2010Pyrim\u00e9thamine as Treatment for Malaria in Pregnant Women","volume":"2","author":"Kalilani L","year":"2007","journal-title":"PLoS ONE"},{"doi-asserted-by":"publisher","key":"e_1_2_11_26_1","DOI":"10.1016\/S0140-6736(09)60997-1"},{"issue":"11","key":"e_1_2_11_27_1","first-page":"CD011444","article-title":"Mefloquine for preventing malaria in pregnant women","volume":"11","author":"Gonz\u00e1lez R","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"unstructured":"Centre belge d'Information Pharmacoth\u00e9rapeutique. 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