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We report 2 cases of atropine overdose after sublingual administration illustrating that atropine can expose to severe adverse effects when administered sublingually. The noncompartmental pharmacokinetic study of atropine performed in 1 patient highlighted that systemic absorption of sublingual atropine was effective (C<jats:sub>max<\/jats:sub> [1 h] = 2.2 ng mL<jats:sup>\u22121<\/jats:sup>; approximately) after a single dose of 1 mg.<\/jats:p>","DOI":"10.1111\/bcp.14757","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T10:57:19Z","timestamp":1612177039000},"page":"3364-3369","source":"Crossref","is-referenced-by-count":16,"title":["Atropine\u2010induced toxicity after off\u2010label sublingual administration of eyedrop for sialorrhoea treatment in neurological disabled patients"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-7178","authenticated-orcid":false,"given":"Hugues","family":"Michelon","sequence":"first","affiliation":[{"name":"Service de Pharmacie H\u00f4pital Sainte\u2010P\u00e9rine, APHP. 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