{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:05:21Z","timestamp":1774897521337,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Rifampicin is a key drug for the treatment of tuberculosis (TB). Little is known for the relationship between the rifampicin pharmacokinetics and genetic polymorphisms in the Asian population. We aimed to investigate relationship between genetic polymorphism of <jats:italic>SLCO1B1<\/jats:italic> and rifampicin exposure and its impact on clinical outcomes in Korean patients with active pulmonary TB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From February 2016 to December 2019, patients with active pulmonary TB who were taking rifampicin for &gt;1 week were prospectively enrolled. Serial or 1\u2010time blood sampling was conducted to determine rifampicin concentrations. The genotype of 4 single nucleotide polymorphisms of <jats:italic>SLCO1B1<\/jats:italic> was determined. To estimate the drug clearance and exposure, population pharmacokinetics analysis was conducted. Clinical outcomes such as time to acid\u2010fast bacteria culture conversion, chest radiograph score changes from baseline, and all\u2010cause mortality were also evaluated. The exposure among different <jats:italic>SLCO1B1<\/jats:italic> genotype was compared and relationship between drug exposure and clinical outcomes were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 105 patients (70 males and 35 females) were included in the final analysis. The mean age of patients was 55.4\u00a0years. The mean drug clearance and exposure were 13.6\u00a0L\/h and 57.9\u00a0mg\u00a0h\/L, respectively. The genetic polymorphisms of <jats:italic>SLCO1B1<\/jats:italic> were not related to rifampicin clearance or exposure. As the rifampicin exposure increased, the chest radiographs improved significantly, but the duration of acid\u2010fast bacteria culture conversion was not related to the drug exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>SLCO1B1<\/jats:italic> gene polymorphisms did not influence rifampicin concentrations and clinical outcomes in Korean patients with active pulmonary TB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14758","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T02:59:51Z","timestamp":1612580391000},"page":"3492-3500","source":"Crossref","is-referenced-by-count":10,"title":["Relationship among genetic polymorphism of <i>SLCO1B1<\/i>, rifampicin exposure and clinical outcomes in patients with active pulmonary tuberculosis"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-5777","authenticated-orcid":false,"given":"Eun Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4188-2786","authenticated-orcid":false,"given":"Jae\u2010Yong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Clinical Trials Center Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Un","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonghae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Clinical Trials Center Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Organization WH.Global tuberculosis report 2020.2020."},{"key":"e_1_2_11_3_1","unstructured":"Prevention KCfDCa.Annual Report on the Notified Tuberculosis Patients in Korea 2017. 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