{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:45:08Z","timestamp":1747183508072,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Recently, letrozole has been used off\u2010label to treat short pubertal boys. The experience on letrozole effectiveness and safety has been obtained primarily from Caucasian children. A simple extrapolation of the data to Chinese paediatric populations is questionable because of the substantial ethnic differences between the two populations. Therefore, the present study aimed to determine the effectiveness and safety of letrozole use in Chinese short pubertal boys as well as to establish an exposure\u2013response relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one Chinese boys were included in the study. Patients were given letrozole tablets (2.5\u00a0mg) once daily in combination with growth hormone, and follow\u2010up visits were made after 1, 3, 6 and 12\u00a0months of treatment. Plasma samples were taken from clinical examinations and analysed using high performance liquid chromatography with fluorescence detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1\u00a0year of treatment, 35 (88%) boys showed increased predicted adult heights. However, possible adverse drug reactions were seen in nine boys (22%). Predicted adult heights increased significantly from 168.4\u00a0\u00b1\u00a03.7 to 173.0\u00a0\u00b1\u00a04.2\u00a0cm, while oestrogen levels dropped from 33.2\u00a0\u00b1\u00a07.4 to 21.6\u00a0\u00b1\u00a07.3\u00a0pg\/mL. Increments in predicted adult height were significantly correlated with trough letrozole concentrations (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.39, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Letrozole treatment in Chinese pubertal populations should be further optimized, and more personalized therapies should be developed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14775","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T09:00:27Z","timestamp":1613293227000},"page":"3599-3607","source":"Crossref","is-referenced-by-count":2,"title":["Off\u2010label use of letrozole in Chinese short pubertal boys: Effectiveness, safety, and exposure\u2013response analysis"],"prefix":"10.1111","volume":"87","author":[{"given":"Yuan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), 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