{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:58:05Z","timestamp":1791824285885,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The multipart Unified Parkinson's Disease Rating Scale is the standard instrument in clinical trials. A sum of scores for all items in 1 or more parts of the instrument is usually analysed. Without accounting for relative importance of individual items, this sum of scores conceivably does not optimize the power of the instrument. The aim was to compare the ability to detect drug effect in slowing down motor function deterioration, as measured by Part III of the Scale\u2014motor examinations\u2014between the item scores and the sum of scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from 423 patients in a Parkinson's disease progression trial to estimate the symptom severity by item response modelling; modelled symptom progression using the severity and the sum of scores; and conducted simulations to compare the sensitivity of detecting a broad range of hypothetical drug effects on progression using the severity and the sum of scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The severity endpoint was far more sensitive than the sum of scores for detecting treatment effects, e.g. requiring 275 <jats:italic>vs<\/jats:italic>. 625 patients per arm to achieve 60% probability of trial success for detecting a range of potential effects in a 2\u2010year trial. Nontremor items related to the left side of the body seemed most informative. The domain relevance of tremor items appeared questionable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This analysis generated clear evidence that longitudinal modelling of item scores can enhance trial efficiency and success. It also called for reassessing the placement of the tremor items in the instrument.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14777","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T04:55:29Z","timestamp":1613192129000},"page":"3608-3618","source":"Crossref","is-referenced-by-count":21,"title":["Modelling item scores of Unified Parkinson's Disease Rating Scale Part III for greater trial efficiency"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-5070","authenticated-orcid":false,"given":"Yucheng","family":"Sheng","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Modelling and Simulation GSK  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Modelling and Simulation GSK  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Modelling and Simulation GSK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiming","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Modelling and Simulation GSK  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Modelling and Simulation GSK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7880-9_5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10473"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26354"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12280"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-017-0058-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-017-2216-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2668-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1315-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-016-9977-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12207"},{"key":"e_1_2_11_16_1","volume-title":"Polytomous Item Response Theory Models","author":"Wilson M","year":"1993"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0146621611425171"},{"key":"e_1_2_11_18_1","unstructured":"ShengY YangS MaP ChenC.Item response theory modelling of motor scores to investigate feasibility of reducing proof\u2010of\u2010concept trial for Parkinson's disease. 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