{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:04Z","timestamp":1787013904218,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Nitrous oxide is an increasingly popular recreational drug. However, recurrent or prolonged use can be associated with nitrous oxide toxicity, with numerous reports of harm documented in the literature. Nitrous oxide irreversibly binds and inactivates vitamin B12, which is an important co\u2010factor in metabolic pathways involved in DNA and myelin synthesis. Toxicity is therefore associated with vitamin B12 deficiency\u2010related syndromes, primarily involving haematological and neurological systems. As a \u201clegal high\u201d, nitrous oxide use has attracted repeated health warnings from experts. An awareness and understanding of the pathophysiology and management of nitrous oxide toxicity is therefore important for clinicians. We discuss the case of a 29\u2010year\u2010old man presenting with nitrous oxide\u2010induced sensorimotor neuropathy and review the existing literature surrounding toxicity.<\/jats:p>","DOI":"10.1111\/bcp.14779","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T03:32:09Z","timestamp":1613446329000},"page":"3622-3626","source":"Crossref","is-referenced-by-count":25,"title":["Nitrous oxide\u2010induced neurotoxicity: A case report and literature review"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-1648","authenticated-orcid":false,"given":"Darmiga","family":"Thayabaran","sequence":"first","affiliation":[{"name":"Whittington Health NHS Trust  Magdala Avenue London N19 5NF UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burrage","sequence":"additional","affiliation":[{"name":"Whittington Health NHS Trust  Magdala Avenue London N19 5NF UK"},{"name":"University College London  Gower Street London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WinstockAR BarrattMJ MaierLJ et al.Global Drug Survey (GDS) 2019 Key Findings Report;2019."},{"issue":"2","key":"e_1_2_9_3_1","first-page":"1","article-title":"Nitrous oxide induced elevation of plasma homocysteine and methylmalonic acid levels and their clinical implication","volume":"8","author":"Kaliki P","journal-title":"Int J Anesthesi"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8040551"},{"key":"e_1_2_9_5_1","unstructured":"Drugs Misuse.Findings from the 2018\/19 Crime Survey for England and Wales (CSEW).https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/832533\/drug-misuse-2019-hosb2119.pdf. 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