{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:40:04Z","timestamp":1792100404105,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Accurate documentation of medication administration time is imperative for many therapeutic decisions, including dosing of intravenous antimicrobials. The objectives were to determine (1) the discrepancy between actual and documented administration times for antimicrobial infusions and (2) whether day of the week, time of day, nurse\u2010to\u2010patient ratio and drug impacted accuracy of documented administration times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient and dosing data were collected (June\u2013August 2019) for 55 in\u2010patients receiving antimicrobial infusions. \u201cDocumented\u201d and \u201cactual\u201d administration times (<jats:italic>n<\/jats:italic>\u2009=\u2009660) extracted from electronic medication management systems and smart infusion pumps, respectively, were compared. Influence of the day (weekday\/weekend), time of day (day\/evening\/night), nurse\u2010to\u2010patient ratio (high 1:1\/low 1:5) and drug were examined. Monte Carlo simulation was used to predict the impact on dose adjustments for vancomycin using the observed administration time discrepancies compared to the actual administration time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median discrepancy between actual and documented administration times was 16\u2009min (range, 2\u2013293\u2009min), with discrepancies greater than 60\u2009minutes in 7.7% of administrations. Overall, discrepancies (median [range]) were similar on weekends (17 [2\u2013293] min) and weekdays (16 [2\u2013188] min), and for high (16 [2\u2013157] min) and low nurse\u2010to\u2010patient ratio wards (16 [2\u2013293] min). Discrepancies were smallest for night administrations (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), and antimicrobials with shorter half\u2010lives (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The observed discrepancies in vancomycin administration time resulted in a different dose recommendation in 58% of cases (30% higher, 28% lower).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, there were discrepancies between actual and documented antimicrobial infusion administration times. For vancomycin, these discrepancies in administration time were predicted to result in inappropriate dose recommendations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14844","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T04:45:31Z","timestamp":1617252331000},"page":"4273-4282","source":"Crossref","is-referenced-by-count":20,"title":["Accuracy of documented administration times for intravenous antimicrobial drugs and impact on dosing decisions"],"prefix":"10.1111","volume":"87","author":[{"given":"Stephanie A.","family":"Roydhouse","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital Sydney Sydney Australia"},{"name":"St Vincent's Clinical School, Faculty of Medicine The University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1456-876X","authenticated-orcid":false,"given":"Jane E.","family":"Carland","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital Sydney Sydney Australia"},{"name":"St Vincent's Clinical School, Faculty of Medicine The University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah S.","family":"Debono","sequence":"additional","affiliation":[{"name":"Centre for Health Services Management, School of Public Health The University of Technology Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-9126","authenticated-orcid":false,"given":"Melissa T.","family":"Baysari","sequence":"additional","affiliation":[{"name":"Sydney School of Health Sciences, Charles Perkins Centre, Faculty of Medicine and Health The University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-7287","authenticated-orcid":false,"given":"Stephanie E.","family":"Reuter","sequence":"additional","affiliation":[{"name":"UniSA Clinical and Health Sciences University of South Australia Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice J.","family":"Staciwa","sequence":"additional","affiliation":[{"name":"Pharmacy Department St Vincent's Hospital Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmol P. 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