{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:01:37Z","timestamp":1787061697832,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The association of renal function and linezolid\u2010induced thrombocytopaenia (LIT) remains controversial. We performed a meta\u2010analysis to determine whether impaired renal function is associated with an increased LIT risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic search of PubMed, EMBASE and the Cochrane Library from inception to February 2021 for eligible studies evaluating the relationship between renal function and LIT. Indicators of renal function included renal impairment (RI), severe RI, haemodialysis status, creatinine clearance rate (Ccr) and estimated glomerular filtration rate (eGFR). Unadjusted\u2002and\u2002adjusted estimates and 95% confidence intervals (CIs) were calculated separately using a random\u2010effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 24 studies with 3580 patients were included in the meta\u2010analysis. RI patients had an increased LIT risk compared to non\u2010RI patients in both the unadjusted (OR 3.54; 95% CI 2.27, 5.54;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 77.7%) and adjusted analyses (OR 2.51; 95% CI 1.82, 3.45;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 17.9%). This association persisted in the subset of studies involving only patients receiving a fixed conventional dose (600\u2009mg every 12\u2009h) and other subgroup analyses by ethnicity, sample size and study quality. Moreover, the LIT risk was significantly higher in patients with severe RI and haemodialysis than in patients without severe RI and haemodialysis. The eGFR and Ccr were significantly lower in LIT patients than in non\u2010LIT patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Impaired renal function is associated with an increased risk of LIT. A reduced linezolid dose may be considered in RI patients at a low risk of treatment failure, ideally guided by therapeutic drug monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.14965","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:10:55Z","timestamp":1625116255000},"page":"464-475","source":"Crossref","is-referenced-by-count":31,"title":["Effect of renal function on the risk of thrombocytopaenia in patients receiving linezolid therapy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-3958","authenticated-orcid":false,"given":"Changcheng","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, 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