{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:33:22Z","timestamp":1791005602309,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Cabotegravir long\u2010acting (LA) intramuscular (IM) injection is being investigated for HIV preexposure prophylaxis due to its potent antiretroviral activity and infrequent dosing requirement. A subset of healthy adult volunteers participating in a Phase I study assessing cabotegravir tissue pharmacokinetics underwent serial magnetic resonance imaging (MRI) to assess drug depot localization and kinetics following a single cabotegravir LA IM targeted injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight participants (four men, four women) were administered cabotegravir LA 600\u2009mg under ultrasonographic\u2010guided injection targeting the gluteal muscles. MRI was performed to determine injection\u2010site location in gluteal muscle (IM), subcutaneous (SC) adipose tissue and combined IM\/SC compartments, and to quantify drug depot characteristics, including volume and surface area, on Days 1 (\u22642\u2009hours postinjection), 3 and 8. Linear regression analysis examined correlations between MRI\u2010derived parameters and plasma cabotegravir exposure metrics, including maximum observed concentration (\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) and partial area under the concentration\u2013time curve (AUC) through Weeks 4 and 8.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cabotegravir LA depot locations varied by participant and were identified in the IM compartment (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02), combined IM\/SC compartments (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04), SC compartment (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01) and retroperitoneal cavity (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01). Although several MRI parameter and exposure metric correlations were determined, total depot surface area on Day 1 strongly correlated with plasma cabotegravir concentration at Days 3 and 8,\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      and partial AUC through Weeks 4 and 8.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      MRI clearly delineated cabotegravir LA injection\u2010site location and depot kinetics in healthy adults. Although injection\u2010site variability was observed, drug depot surface area correlated with both plasma\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      and partial AUC independently of anatomical distribution.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.14977","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T23:24:17Z","timestamp":1625786657000},"page":"1655-1666","source":"Crossref","is-referenced-by-count":36,"title":["Multiparametric magnetic resonance imaging to characterize cabotegravir long\u2010acting formulation depot kinetics in healthy adult volunteers"],"prefix":"10.1111","volume":"88","author":[{"given":"Beat M.","family":"Jucker","sequence":"first","affiliation":[{"name":"GlaxoSmithKline  Collegeville PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward 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