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This study evaluated a case series of patients with Chagas heart disease who used sacubitril\/valsartan at a referral hospital for this disease in Brazil. After 6\u2009months, there was a symptomatic improvement in these individuals assessed by the New York Heart Association (NYHA) functional class, with a 44.3% reduction in the absolute number of patients classified as III\u2013IV in the period (<jats:italic>P<\/jats:italic>\u2009=\u20090.035), but without changes in the parameters on the echocardiogram for reverse ventricular remodelling. There was a high mortality rate and number of hospitalizations. These results emphasize the importance of studying the use of sacubitril\/valsartan in Chagas heart disease to better describe its effectiveness considering the particularities of these individuals.<\/jats:p>","DOI":"10.1111\/bcp.14978","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:51:08Z","timestamp":1625806268000},"page":"429-436","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and echocardiographic characteristics after six months of sacubitril\/valsartan in Chagas heart disease \u2013 A case series"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-9087","authenticated-orcid":false,"given":"Clara Salles","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Federal University of Bahia  Rua Augusto Viana, s\/n Salvador Bahia 40110\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Morel Vieira","family":"de Melo","sequence":"additional","affiliation":[{"name":"Federal University of Bahia  Rua Augusto Viana, s\/n Salvador Bahia 40110\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina Teixeira","family":"Viana","sequence":"additional","affiliation":[{"name":"Federal University of Bahia  Rua Augusto Viana, s\/n Salvador Bahia 40110\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Grimaldi Queiroz","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Ana Nery Hospital  R. Saldanha Marinho, s\/n \u2010 Caixa D'agua Salvador Bahia 40301\u2010155 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tainara Cerqueira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Ana Nery Hospital  R. Saldanha Marinho, s\/n \u2010 Caixa D'agua Salvador Bahia 40301\u2010155 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Mamedio","family":"da Silva","sequence":"additional","affiliation":[{"name":"Ana Nery Hospital  R. Saldanha Marinho, s\/n \u2010 Caixa D'agua Salvador Bahia 40301\u2010155 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Neves","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Federal University of Bahia  Rua Augusto Viana, s\/n Salvador Bahia 40110\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Nascimento Valame","family":"da Silva","sequence":"additional","affiliation":[{"name":"Ana Nery Hospital  R. Saldanha Marinho, s\/n \u2010 Caixa D'agua Salvador Bahia 40301\u2010155 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos Santana","family":"Passos","sequence":"additional","affiliation":[{"name":"Federal University of Bahia  Rua Augusto Viana, s\/n Salvador Bahia 40110\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000599"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.11.057"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Does left ventricular reverse remodeling influence long\u2010term outcomes in patients with Chagas cardiomyopathy?","author":"Nakazone MA","year":"2020","journal-title":"Cardiol J"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/849504"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.004"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"436","article-title":"Diretriz brasileira de insufici\u00eancia card\u00edaca cr\u00f4nica e aguda","volume":"111","author":"Rohde LEP","year":"2018","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.06.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.882035"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00181-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.12.017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12344"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12355"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.508093"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.10.008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012272"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12435"},{"issue":"6","key":"e_1_2_10_20_1","first-page":"108","article-title":"Ejection fraction improvement and reverse remodeling achieved with sacubitril\/valsartan in heart failure with reduced ejection fraction patients","volume":"7","author":"Almufleh A","year":"2017","journal-title":"Am J Cardiovasc Dis"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060301"},{"issue":"4","key":"e_1_2_10_22_1","first-page":"273","article-title":"Acao benefica do enalapril sobre a funcao diastolica ventricular na miocardiopatia da doenca de Chagas","volume":"60","author":"Szajnbok FEK","year":"1993","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.05.005"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.14978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:13:48Z","timestamp":1692850428000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,31]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/bcp.14978"],"URL":"https:\/\/doi.org\/10.1111\/bcp.14978","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,31]]}}}