{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:54:22Z","timestamp":1770569662995,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1124130"],"award-info":[{"award-number":["APP1124130"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1130301"],"award-info":[{"award-number":["APP1130301"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008127","name":"Universiti Malaysia Sarawak","doi-asserted-by":"publisher","award":["F05\/TDG\/1734\/2018"],"award-info":[{"award-number":["F05\/TDG\/1734\/2018"]}],"id":[{"id":"10.13039\/501100008127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to assess the pharmacokinetic properties of artemether, lumefantrine and their active metabolites in <jats:italic>Plasmodium knowlesi<\/jats:italic> malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Malaysian adults presenting with uncomplicated <jats:styled-content style=\"fixed-case\"><jats:italic>P. knowlesi<\/jats:italic><\/jats:styled-content> infections received six doses of artemether (1.7\u00a0mg\/kg) plus lumefantrine (10\u00a0mg\/kg) over 3\u00a0days. Venous blood and dried blood spot (DBS) samples were taken at predetermined time\u2010points over 28\u2009days. Plasma and DBS artemether, dihydroartemisinin, lumefantrine and desbutyl\u2010lumefantrine were measured using liquid chromatography\u2010mass spectrometry. Multi\u2010compartmental population pharmacokinetic models were developed using plasma with or without DBS drug concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one participants (mean age 45\u2009years, 66% males) were recruited. Artemether\u2010lumefantrine treatment was well tolerated and parasite clearance was prompt. Plasma and DBS lumefantrine concentrations were in close agreement and were used together in pharmacokinetic modelling, but only plasma concentrations of the other analytes were used because of poor correlation with DBS levels. The areas under the concentration\u2013time curve (AUC<jats:sub>0\u2013\u221e<\/jats:sub>) for artemether, dihydroartemisinin and lumefantrine (medians 1626, 1881 and 625\u2009098\u2009\u03bcg.h\/L, respectively) were similar to those reported in previous pharmacokinetic studies in adults and children. There was evidence of auto\u2010induction of artemether metabolism (mean increase in clearance relative to bioavailability 25.2% for each subsequent dose). The lumefantrine terminal elimination half\u2010life (median 9.5\u00a0days) was longer than reported in healthy volunteers and adults with falciparum malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The disposition of artemether, dihydroartemisinin and lumefantrine in knowlesi malaria largely parallels that in other human malarias. DBS lumefantrine concentrations can be used in pharmacokinetic studies but DBS technology is currently unreliable for the other analytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15001","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T07:15:27Z","timestamp":1627024527000},"page":"691-701","source":"Crossref","is-referenced-by-count":3,"title":["The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with <i>Plasmodium knowlesi<\/i> malaria"],"prefix":"10.1111","volume":"88","author":[{"given":"Sri Riyati","family":"Sugiarto","sequence":"first","affiliation":[{"name":"University of Western Australia, Medical School, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Universiti Malaysia Sarawak (UNIMAS) Malaria Research Centre  Kota Samarahan Sarawak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu","family":"Page\u2010Sharp","sequence":"additional","affiliation":[{"name":"School of Pharmacy Curtin University of Technology  Bentley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy A.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Western Australia, Medical School, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8276-6784","authenticated-orcid":false,"given":"Sam","family":"Salman","sequence":"additional","affiliation":[{"name":"University of Western Australia, Medical School, Fremantle Hospital  Fremantle Western Australia Australia"},{"name":"Clinical Pharmacology and Toxicology, PathWest  Nedlands Western Australia Australia"},{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases Telethon Kids Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"King Ching","family":"Hii","sequence":"additional","affiliation":[{"name":"Kapit Hospital  Kapit Sarawak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7411","authenticated-orcid":false,"given":"Timothy M. E.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Western Australia, Medical School, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"The Primate Malarias","author":"Coatney GR","year":"1971"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15836-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008900"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/524888"},{"key":"e_1_2_10_6_1","volume-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2015"},{"key":"e_1_2_10_7_1","volume-title":"Management Guidelines of Malaria in Malaysia","author":"Ministry of Health Malaysia","year":"2014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06650.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00267-15"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix779"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2001.01395.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.972-977.2000"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.717"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-S1-S4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1969.11686647"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.060038"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.13.180"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2016.1129273"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.2966-2972.2004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05136-11"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002015"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.294"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01312-10"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.25"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05013-14"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012299115260"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01588-16"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01785.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199918060-00006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.697-704.2000"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.241"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.59"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61492-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00063-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/605439"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01605-15"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0456-7"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-121510-133540"},{"issue":"10","key":"e_1_2_10_40_1","first-page":"CD008492","article-title":"Artemisinin\u2010based combination therapy for treating uncomplicated Plasmodium vivax malaria","author":"Gogtay N","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_10_41_1","first-page":"CD005564","article-title":"Artemether\u2010lumefantrine (six\u2010dose regimen) for treating uncomplicated falciparum malaria","author":"Omari AA","year":"2005","journal-title":"Cochrane Database Syst Rev"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:11:14Z","timestamp":1692850274000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/bcp.15001"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15001","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]}}}