{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:32:30Z","timestamp":1785591150199,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["HSRI. 64\u2010080"],"award-info":[{"award-number":["HSRI. 64\u2010080"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015396","name":"Thailand Center of Excellence for Life Sciences","doi-asserted-by":"publisher","award":["TC\u201012\/63"],"award-info":[{"award-number":["TC\u201012\/63"]}],"id":[{"id":"10.13039\/100015396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Carbamazepine (CBZ) is one of the most common causative drugs of severe cutaneous adverse drug reactions (SCARs) including Stevens\u2013Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reactions with eosinophilia and systemic symptoms. Although genetic polymorphisms of the human leucocyte antigens (<jats:italic>HLA<\/jats:italic>) are well recognized key elements for the susceptibility to CBZ\u2010induced SCARs, some evidence suggest that polymorphisms of microsomal epoxide hydrolase 1 (<jats:italic>EPHX1<\/jats:italic>) may also contribute to the risk of these SCARs. This study investigated the association between the <jats:italic>HLA<\/jats:italic> and <jats:italic>EPHX1<\/jats:italic> polymorphisms on CBZ\u2010induced SCARs in large sample sizes and well\u2010defined SCARs patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one CBZ\u2010induced SCARs Thai patients and 144 CBZ\u2010tolerant patients were enrolled in the study. The genotypes of <jats:italic>HLA\u2010A<\/jats:italic>, <jats:italic>HLA\u2010B<\/jats:italic> and <jats:italic>EPHX1<\/jats:italic> were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 2 <jats:italic>HLA<\/jats:italic> alleles including <jats:italic>HLA\u2010B*15:02<\/jats:italic> and <jats:italic>HLA\u2010A*24:07<\/jats:italic> were statistically significant association with CBZ\u2010induced SJS\/TEN. The highest risk was observed in patients with <jats:italic>HLA\u2010B*15:02<\/jats:italic> allele (OR\u2009=\u200944.33, 95% confidence interval\u2009=\u200920.24\u201397.09, corrected <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20096.80\u2009\u00d7 10<jats:sup>\u221229<\/jats:sup>). Moreover, HLA\u2010B75 serotypes were significantly associated with CBZ\u2010induced SJS\/TEN groups with an odds ratio of 81.00 (95% confidence interval\u2009=\u200932.39\u2013202.56, corrected <jats:italic>P<\/jats:italic>\u2010value =\u20093.84 \u00d7 10<jats:sup>\u221234<\/jats:sup>). There is no association between <jats:italic>EPHX1<\/jats:italic> c.337\u2009T\u2009&gt;\u2009C polymorphism and all phenotypes of CBZ\u2010induced SCARs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>HLA\u2010B*15:02<\/jats:italic> allele is the strongest genetic marker for the prediction of SJS\/TEN induced by CBZ in Thai population. Screening for other alleles in the HLA\u2010B75 serotype increases sensitivity for prediction of a life\u2010threatening SCARs caused by CBZ.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15022","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T06:52:15Z","timestamp":1628146335000},"page":"773-786","source":"Crossref","is-referenced-by-count":20,"title":["Genetic variants associated with severe cutaneous adverse drug reactions induced by carbamazepine"],"prefix":"10.1111","volume":"88","author":[{"given":"Nontaya","family":"Nakkam","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parinya","family":"Konyoung","sequence":"additional","affiliation":[{"name":"Pharmacy Unit, Udon Thani Hospital  Udon Thani 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