{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:15:24Z","timestamp":1790176524127,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Influenza infection poses a severe threat to pregnant mothers, and antiviral treatment is recommended. However, the safety of neuraminidase\u2010inhibitor antiviral medications during pregnancy has not been well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis were performed to evaluate the adverse neonatal outcomes associated with exposure to neuraminidase inhibitors during pregnancy. The PubMed, Embase and Cochrane Library databases were searched to identify potential studies for inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine cohort studies that estimated adverse neonatal outcomes associated with exposure to neuraminidase\u2010inhibitor medication during pregnancy were included. Exposure to a neuraminidase inhibitor during pregnancy was not associated with an increased risk of congenital malformation (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.72\u20101.12, <jats:italic>P<\/jats:italic>\u2009=\u2009.341), low Apgar score (OR 0.96, 95% CI 0.77\u20101.2, <jats:italic>P<\/jats:italic>\u2009=\u2009.733) or preterm birth (OR 0.99, 95% CI 0.89\u20101.09, <jats:italic>P<\/jats:italic>\u2009=\u2009.771) compared with no exposure. However, exposure to a neuraminidase inhibitor was associated with a reduced risk of low birth weight (OR 0.79, 95% CI 0.68\u20100.92, <jats:italic>P<\/jats:italic>\u2009=\u2009.002) and giving birth to a small\u2010for\u2010gestational\u2010age infant (OR 0.78, 95% CI 0.69\u20100.88, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Further analyses limited to oseltamivir exposure were consistent with the overall results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to neuraminidase\u2010inhibitor medication during pregnancy does not appear to be associated with adverse neonatal outcomes. We recommend further studies to investigate this association, which will help clinicians determine whether to prescribe a neuraminidase inhibitor during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15033","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T04:54:58Z","timestamp":1628657698000},"page":"911-918","source":"Crossref","is-referenced-by-count":7,"title":["Neonatal outcomes after neuraminidase inhibitor use during pregnancy: A meta\u2010analysis of cohort studies"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4419-2027","authenticated-orcid":false,"given":"Jiangshan","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi China"},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4111-507X","authenticated-orcid":false,"given":"Munire","family":"Adilijiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-7811","authenticated-orcid":false,"given":"Caihua","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-7827","authenticated-orcid":false,"given":"Haiyin","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2267-6434","authenticated-orcid":false,"given":"Yongping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.01.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.12.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.095"},{"key":"e_1_2_9_5_1","unstructured":"CfDCa P.Updated Interim Recommendations for Obstetric Health Care Providers Related to Use of Antiviral Medications in the Treatment and Prevention of Influenza for the 2009\u20102010 Season. 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