{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:44:08Z","timestamp":1791081848723,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Diverse genetic and\/or external factors may induce psoriasis. Drug exposure is 1 such prominent external factor; antihypertensive drugs are reportedly associated with psoriasis, but study results have been inconsistent. In this context, we investigated the associations between antihypertensive drugs and incidence if psoriasis via a systematic literature review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search in databases such as PubMed, Embase and Web of Science was conducted on 8 January 2021, and obtained data were pooled for meta\u2010 and network meta\u2010analysis. Fixed\u2010 or random effect models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for evaluating the strength of the associations between antihypertensive drugs and psoriasis incidence. In addition to meta\u2010analysis, Bayesian network meta\u2010analysis was performed.<\/jats:p><jats:p>ResultsThirteen eligible studies were included for meta\u2010analysis with 6\u2009378\u2009116 individuals and 8 studies for network meta\u2010analysis with 5\u2009615\u2009918 individuals. All antihypertensive drugs were significantly associated with psoriasis incidence. In a meta\u2010analysis, the pooled ORs were 1.67 (95% CI: 1.31\u20132.13) for angiotensin\u2010converting enzyme (ACE) inhibitors, 1.40 (95% CI: 1.20\u20131.63) for \u03b2\u2010blockers, 1.53 (95% CI: 1.23\u20131.89) for calcium\u2010channel blockers (CCBs), and 1.70 (95% CI: 1.40\u20132.06) for thiazide diuretics. For the comparative risks of psoriasis among antihypertensive drugs in the network meta\u2010analysis, ORs were 2.09 (95% CI: 1.39\u20133.18) for ACE inhibitors, 1.35 (95% CI: 0.99\u20131.91) for BBs, 1.53 (95% CI: 1.07\u20132.24) for CCBs and 1.80 (95% CI: 1.23\u20132.66) for thiazide diuretics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirmed the associations between antihypertensive drugs and psoriasis; ACE inhibitors, BBs, CCBs and thiazide diuretics increased the risk of psoriasis. Therefore, antihypertensive drug users should be carefully monitored for psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15060","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T05:00:43Z","timestamp":1633669243000},"page":"933-941","source":"Crossref","is-referenced-by-count":17,"title":["Antihypertensive drug use and psoriasis: A systematic review, meta\u2010 and network meta\u2010analysis"],"prefix":"10.1111","volume":"88","author":[{"given":"Gonjin","family":"Song","sequence":"first","affiliation":[{"name":"College of Pharmacy and Graduate School of Pharmaceutical Sciences Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Graduate School of Pharmaceutical Sciences Ewha Womans University  Seoul Republic of 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