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The aim was to establish their value\u2010based price under conditions of uncertainty surrounding their tolerability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A discrete\u2010time Markov model was developed to assess the value\u2010based price of oral iron preparations based on their incremental cost per quality\u2010adjusted life year (QALY) gained from the perspective of the NHS in the UK. Primary and secondary care resource use and health state occupancy probabilities were estimated from routine electronic health records; and unit costs and health state utilities were derived from published sources. Patients were pre\u2010menopausal women with iron deficiency anaemia who were prescribed oral iron supplementation between 2000 and 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The model reflecting current use of iron salts yielded a mean total cost to the NHS of \u00a3779, and 0.84 QALYs over 12\u2009months. If a new iron preparation were to reduce the risk of adverse drug reactions by 30\u201340%, then its value\u2010based price, based on a threshold of \u00a320\u2009000 per QALY, would be in the region of \u00a310\u2013\u00a313 per month, or about 7\u20139 times the average price of basic iron salts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are no adequate, direct comparisons of new oral iron supplements to ferrous iron salts, and therefore other approaches are needed to assess their value. Our modelling shows that they are potentially cost\u2010effective at prices that are an order of magnitude higher than existing iron salts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15078","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T18:28:15Z","timestamp":1631471295000},"page":"1347-1357","source":"Crossref","is-referenced-by-count":2,"title":["Novel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug?"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-4255","authenticated-orcid":false,"given":"Giovanna","family":"Culeddu","sequence":"first","affiliation":[{"name":"Centre for Health Economics and Medicines Evaluation Bangor University  Bangor United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-3462","authenticated-orcid":false,"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit, School of Clinical Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit, School of Clinical Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-4448","authenticated-orcid":false,"given":"Dora I. 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