{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:41:11Z","timestamp":1777905671444,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013235","name":"NIHR Greater Manchester Patient Safety Translational Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the prevalence of potentially hazardous prescribing in the prison setting using prescribing safety indicators (PSIs) and explore their implementation and use in practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PSIs were identified and reviewed by the project team following a literature review and a nominal group discussion. Pharmacists at 2 prison sites deployed the PSIs using search protocols within their electronic health record. Prevalence rates and 95% confidence intervals (CIs) were generated for each indicator. Semi\u2010structured interviews with 20 prison healthcare staff across England and Wales were conducted to explore the feasibility of deploying and using PSIs in prison settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen PSIs were successfully deployed mostly comprising drug\u2013drug interactions (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). Five yielded elevated prevalence rates: use of anticholinergics if aged \u226565\u2009years (Site B: 25.8% [95%CI: 10.4\u201341.2%]), lack of antipsychotic monitoring for &gt;12\u2009months (Site A: 39.1% [95%CI: 27.1\u201352.1%]; Site B: 28.6% [95%CI: 17.9\u201341.4%]), prolonged use of hypnotics (Site B: 46.3% [95%CI: 35.6\u201357.1%]), antiplatelets prescribed with nonsteroidal anti\u2010inflammatory drugs without gastrointestinal protection (Site A: 12.5% [95%CI: 0.0\u201335.4%]; Site B: 16.7% [95%CI: 0.4\u201364.1%]), and selective serotonin\/norepinephrine reuptake inhibitors prescribed with nonsteroidal anti\u2010inflammatory drugs\/antiplatelets without gastrointestinal protection (Site A: 39.6% [95%CI: 31.2\u201348.4%]; Site B: 33.3% [95%CI: 20.8\u201347.9%]). Prison healthcare staff supported the use of PSIs and identified key considerations to guide its successful implementation, including staff engagement and PSI 'champions'. To respond to PSI searches, stakeholders suggested contextualised patient support through intraprofessional collaboration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We successfully implemented a suite of PSIs into 2 prisons, identifying those with higher prevalence values as intervention targets. When appropriately resourced and integrated into staff workflow, PSI searches may support prescribing safety in prisons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15107","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T11:10:59Z","timestamp":1633777859000},"page":"1866-1884","source":"Crossref","is-referenced-by-count":16,"title":["Implementing prescribing safety indicators in prisons: A mixed methods study"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4073-4346","authenticated-orcid":false,"given":"Aseel S.","family":"Abuzour","sequence":"first","affiliation":[{"name":"Division of Pharmacy &amp; Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Suicide, Risk and Safety Research Unit Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esnath","family":"Magola\u2010Makina","sequence":"additional","affiliation":[{"name":"Division of Pharmacy &amp; Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Suicide, Risk and Safety Research Unit Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Dunlop","sequence":"additional","affiliation":[{"name":"Suicide, Risk and Safety Research Unit Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Her Majesty's Prison Berwyn Wrexham Industrial Estate  Wrexham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9489-1697","authenticated-orcid":false,"given":"Wael Y.","family":"Khawagi","sequence":"additional","affiliation":[{"name":"Division of Pharmacy &amp; Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Department of Clinical Pharmacy College of Pharmacy, Taif University  Taif Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-915X","authenticated-orcid":false,"given":"Darren M.","family":"Ashcroft","sequence":"additional","affiliation":[{"name":"Division of Pharmacy &amp; Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Suicide, Risk and Safety Research Unit Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"},{"name":"NIHR Greater Manchester Patient Safety Translational Research Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Brown","sequence":"additional","affiliation":[{"name":"Suicide, Risk and Safety Research Unit Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"},{"name":"Pharmacy Department Pennine Care NHS Foundation Trust, Ashton\u2010Under\u2010Lyne  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-8154","authenticated-orcid":false,"given":"Richard N.","family":"Keers","sequence":"additional","affiliation":[{"name":"Division of Pharmacy &amp; Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Suicide, Risk and Safety Research Unit Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"},{"name":"NIHR Greater Manchester Patient Safety Translational Research Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organisation.Prisons and Health.2014. Accessed 30 July 2021. Available from:https:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0005\/249188\/Prisons-and-Health.pdf"},{"key":"e_1_2_11_3_1","unstructured":"SingletonN MeltzerH GatwardR CoidJ DeasyD.Psychiatric morbidity among prisoners: Summary report 1997. Accessed 30 July 2021. Available from:https:\/\/data.gov.uk\/dataset\/dd6e8c95-be7d-49dc-87db-14ea1fb5ce00\/psychiatric-morbidity-among-prisoners"},{"key":"e_1_2_11_4_1","unstructured":"Survey of the Physical Health of Prisoners 1994: A survey of sentenced male prisoners in England and Wales carried out by the Social Survey Division of OPCS on behalf of the Prison Service Health Care Directorate. Office of Population Censuses & Surveys; 1994. Accessed 30 July 2021."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.55.5.364"},{"key":"e_1_2_11_6_1","unstructured":"Magola\u2010MakinaE AbuzourAS AshcroftDM BrownP KeersRN.Exploring the challenges to safer prescribing and medication monitoring in prisons: a qualitative study with health care staff [submitted]."},{"key":"e_1_2_11_7_1","unstructured":"WHO Regional Office for Europe.Status report on prison health in the WHO European Region.2019. CC BY\u2010NC\u2010SA 3.0 IGO. Accessed 30 July 2021. Available from:https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/329943\/9789289054584-eng.pdf"},{"key":"e_1_2_11_8_1","unstructured":"Public Health England.Rapid review of evidence of the impact on health outcomes of NHS commissioned health services for people in secure and detained settings to inform future health interventions and prioritisation in England.2016. Accessed 30 July 2021. Available from:https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/565231\/Rapid_review_health_outcomes_secure_detained_settings_.pdf"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2019.43"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1055-7"},{"key":"e_1_2_11_11_1","unstructured":"Prison Reform Trust.Prisons Can Seriously Damage Your Mental Health. Accessed 30 July 2021. Available from:http:\/\/www.prisonreformtrust.org.uk\/uploads\/documents\/Mentalhealthsmall.pdf"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X588501"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61817-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.14236\/jhi.v25i3.1015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12087"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003286"},{"key":"e_1_2_11_17_1","unstructured":"MatosAApplying Prescribing Safety Indicators to Health and Justice Sites. Specialist Pharmacy Service Accessed August 2020. Available from:https:\/\/www.sps.nhs.uk\/articles\/applying-prescribing-safety-indicators-to-health-and-justice-sites\/"},{"key":"e_1_2_11_18_1","unstructured":"The Phoenix Partnership (TPP).Transforming the delivery of health and care. Accessed 28 August 2020. Available from:https:\/\/www.tpp-uk.com\/about"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp14X677806"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14391"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1108\/13522751211191964"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7748\/nr.22.3.35.e1297"},{"key":"e_1_2_11_23_1","unstructured":"NHS Digital.Read Codes. Accessed 30 July 2021. Available from:https:\/\/digital.nhs.uk\/services\/terminology-and-classifications\/read-codes#:~:text=Read%20Codes%20are%20a%20coded 3%20(CTV3%20or%20v3)"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/13620-004"},{"key":"e_1_2_11_25_1","unstructured":"NHS England.The NHS Patient Safety Strategy. Accessed 30 July 2021. Available From:https:\/\/www.england.nhs.uk\/patient-safety\/the-nhs-patient-safety-strategy\/"},{"key":"e_1_2_11_26_1","unstructured":"World Health Organisation.Medication Without Harm \u2010 Global Patient Safety Challenge on Medication Safety.2017. CC BY\u2010NC\u2010SA 3.0 IGO. Accessed 30 July 2021. Available from:https:\/\/www.who.int\/publications\/i\/item\/WHO-HIS-SDS-2017.6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.12.018"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20420"},{"key":"e_1_2_11_29_1","unstructured":"SturgeG.UK Prison Population Statistics.2020. Accessed 30 July 2021. Available from:https:\/\/commonslibrary.parliament.uk\/research-briefings\/sn04334\/"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0677"},{"key":"e_1_2_11_31_1","unstructured":"Royal College of General Practitioners.Safer Prescribing in Prisons \u2010 Guidance for clinicans.2019. Accessed August 2020. Available from:https:\/\/www.rcgp.org.uk\/-\/media\/Files\/Policy\/2019\/RCGP-safer-prescribing-in-prisons-guidance-jan-2019.ashx?la=en"},{"key":"e_1_2_11_32_1","unstructured":"Specialist Pharmacy Service.What is the risk of gastrointestinal bleeding associated with selective serotonin reuptake inhibitors (SSRIs)? Updated 17 October 2019. Accessed 28 August 2020. Available from:https:\/\/www.sps.nhs.uk\/articles\/what-is-the-risk-of-gastrointestinal-bleeding-associated-with-selective-serotonin-reuptake-inhibitors-ssris"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5501"},{"key":"e_1_2_11_34_1","unstructured":"Prison Service Order.Continuity of healthcare for prisoners.2006. Order number 3050. Accessed 30 July 2021. Available from:https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/922804\/PSO_3050_continuity_of_healthcare_for_prisoners.pdf"},{"key":"e_1_2_11_35_1","unstructured":"Office for National Statistics.Deaths related to drug poisoning in England and Wales: 2016 registrations.2017. Accessed 30 July 2021. Available from:https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/deaths\/bulletins\/deathsrelatedtodrugpoisoninginenglandandwales\/2016registrations"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205419"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-78"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-016-0531-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-4458-3-24"},{"key":"e_1_2_11_40_1","unstructured":"FarmerD.Medicines Optimisation in Health and Justice Services: Report from a National Audit of Professional Standards. 2019. Accessed 30 July 2021.https:\/\/www.sps.nhs.uk\/wp-content\/uploads\/2018\/06\/Medicines-Optimisation-in-Secure-Environments-Audit-report-SPS-June-2019.pdf"},{"key":"e_1_2_11_41_1","unstructured":"Acute Care and Workforce.The Report of the Short Life Working Group on Reducing Medication\u2010Related Harm.2018. Accessed 30 July 2021.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/683430\/short\u2010life\u2010working\u2010group\u2010report\u2010on\u2010medication\u2010errors.pdf"},{"key":"e_1_2_11_42_1","unstructured":"Prison Reform Trust.Welcome to the Women's Programme. Accessed 2nd October 2020.http:\/\/www.prisonreformtrust.org.uk\/WhatWeDo\/Projectsresearch\/Women"},{"key":"e_1_2_11_43_1","unstructured":"Ministry of Justice.Working in the Prison Service. Accessed 30 July 2021.https:\/\/prisonjobs.blog.gov.uk\/your-a-d-guide-on-prison-categories\/"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","DOI":"10.3310\/hsdr03420","volume-title":"Measuring prevalence, reliability and variation in high\u2010risk prescribing in general practice using multilevel modelling of observational data in a population database","author":"Guthrie B","year":"2015"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:16:50Z","timestamp":1693005410000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/bcp.15107"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15107","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]}}}