{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:34:24Z","timestamp":1792010064321,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/19256\u20106"],"award-info":[{"award-number":["2017\/19256\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>No study has evaluated the betamethasone pharmacokinetics in twin pregnancies according to chorionicity. This study aimed to describe and compare the betamethasone pharmacokinetic parameters in singleton and dichorionic (DC) and monochorionic twin pregnancies in the third trimester of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six pregnant women received 2 intramuscular doses of 6\u00a0mg of betamethasone sodium phosphate plus 6\u00a0mg betamethasone acetate due to preterm labour. Serial blood samples were collected for 24\u2009hours after the first intramuscular dose of betamethasone esters. Betamethasone plasma concentrations were quantified using a validated liquid chromatography\u2013tandem mass spectrometry analytical method, and the pharmacokinetic parameters were obtained employing a noncompartmental model. Preliminary data on the betamethasone placental transfer are also presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The geometric mean (95% confidence interval) of AUC<jats:sup>0\u2010\u221e<\/jats:sup> 645.1 (504.3\u2013825.2) <jats:italic>vs<\/jats:italic>. 409.8 (311.2\u2013539.6) ng.h\/mL and CL\/F 17.70 (13.84\u201322.65) <jats:italic>vs<\/jats:italic>. 27.87 (21.17\u201336.69) were significantly different, respectively, in singleton pregnancies when compared to DC twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data from this study suggest that the presence of 2 foetoplacental units may increase the betamethasone metabolism by hepatic CYP3A4 and\/or placental 11\u03b2\u2010HSD2 enzymes. Pharmacokinetic\u2013pharmacodynamic clinical studies are needed to investigate whether these betamethasone pharmacokinetic changes have clinical repercussions for the newborns and require dose adjustment in DC twin pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15111","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:28:06Z","timestamp":1634765286000},"page":"1897-1903","source":"Crossref","is-referenced-by-count":9,"title":["Enhanced elimination of betamethasone in dichorionic twin pregnancies"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-1332","authenticated-orcid":false,"given":"Grazielle de F\u00e1tima Pinto","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhohann Richard de Lima","family":"Benzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Helena de Castro","family":"Matos","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella Felippe","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo de Carvalho","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Christine Dantas","family":"Mois\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-4953","authenticated-orcid":false,"given":"Vera Lucia","family":"Lanchote","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Cristina","family":"Marcolin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290065031"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts D","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_4_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"3","author":"Roberts D","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2018.04.018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001711"},{"key":"e_1_2_12_7_1","unstructured":"WHO.World Health Organization.Recommendations on Interventions to Improve Preterm Birth Outcomes.2015."},{"key":"e_1_2_12_8_1","unstructured":"National Institute for Health and Care Excellence.Preterm Labour and Birth. 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