{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:48:11Z","timestamp":1789832891560,"version":"4.0.1"},"reference-count":82,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72074005"],"award-info":[{"award-number":["72074005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A lot of medication risks related to high\u2010dose methotrexate (HDMTX) therapy still remain to be identified and standardized. This study aims to establish an evidence\u2010based practice guideline for individualized medication of HDMTX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The practice guideline was launched by the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society. The guideline was developed following the WHO handbook for guideline development and the methodology of evidence\u2010based medicine (EBM). The guideline was initially registered in the International Practice Guidelines Registry Platform (IPGRP\u20102017CN021). Systematic reviews were conducted to synthesize available evidence. A multicentre cross\u2010sectional study was conducted using questionnaires to evaluate patients' perception and willingness concerning individualized medication of HDMTX. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to rate the quality of evidence and to grade the strength of recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multidisciplinary working groups were included in this guideline, including clinicians, pharmacists, methodologists, pharmacologists and pharmacoeconomic specialists. A total of 124 patients were involved to integrate patient values and preferences. Finally, the guideline presents 28 recommendations, regarding evaluation prior to administration (renal function, liver function, pleural effusion, comedications, genetic testing), pre\u2010treatment and routine dosing regimen, therapeutic drug monitoring (necessity, method, timing, target concentration), leucovorin rescue (initial timing, dosage regimen and optimization), and management of toxicities. Of these, 12 are strong recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We developed an evidence\u2010based practice guideline with respect to HDMTX medication using a rigorous and multidisciplinary approach. This guideline provides comprehensive and practical recommendations involving the whole process of HDMTX administration to health care providers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15134","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T22:06:23Z","timestamp":1635890783000},"page":"2456-2472","source":"Crossref","is-referenced-by-count":40,"title":["Medication therapy of high\u2010dose methotrexate: An evidence\u2010based practice guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society"],"prefix":"10.1111","volume":"88","author":[{"given":"Zaiwei","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"},{"name":"Therapeutic Drug Monitoring and Clinical Toxicology Center Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"},{"name":"Therapeutic Drug Monitoring and Clinical Toxicology Center Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"},{"name":"Therapeutic Drug Monitoring and Clinical Toxicology Center Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"},{"name":"Therapeutic Drug Monitoring and Clinical Toxicology Center Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-359X","authenticated-orcid":false,"given":"Suodi","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"},{"name":"Therapeutic Drug Monitoring and Clinical Toxicology Center Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010Based Medicine Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica Chinese Academy of Medical Sciences &amp; 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