{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:46:25Z","timestamp":1787942785399,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acute neutropenia induced by antibiotics is a rare side effect of this frequently prescribed class of drugs. We aim to find similarities and differences between reported cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Through a database search (PubMed, 1968\u20132020), we identified published case reports and extracted, among other data, patient demographics, duration of treatment with the respective agent, and duration of recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 83 cases were included. Neutropenia developed after a median (min\u2013max) of 21 (17.5\u201328.5) days of treatment and was resolved after a median (min\u2013max) of 6 (3.0\u20138.75) days.\n                      <jats:italic>Vancomycin<\/jats:italic>\n                      and\n                      <jats:italic>ceftaroline<\/jats:italic>\n                      emerged as the two most commonly described antibiotics. In 51.8% of cases, the suspected antibiotic was discontinued; in 37.4% of cases, it was substituted by another agent. Only three case reports mentioned death as a result of neutropenia. The use of granulocyte colony\u2010stimulating growth factors (CSFs) shortened the duration of neutropenia and improved outcome for patients' health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neutropenia induced by antibiotics remains a rare or rarely reported side effect. Long\u2010term and high\u2010dose treatment regimens expose a higher risk of development. Thus, regular full blood counts are advised during therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15170","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T22:36:30Z","timestamp":1639348590000},"page":"1978-1984","source":"Crossref","is-referenced-by-count":18,"title":["Acute antibiotically induced neutropenia: A systematic review of case reports"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-4226","authenticated-orcid":false,"given":"Julian M.","family":"Holz","sequence":"first","affiliation":[{"name":"Faculty of Medicine Riga Stradins University  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-4455","authenticated-orcid":false,"given":"Alon V.","family":"Chevtchenko","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Riga Stradins University  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-7636","authenticated-orcid":false,"given":"Aleksandra","family":"Aitullina","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Paul Stradins Clinical University Hospital Riga Stradins University  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.3.323"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.187"},{"key":"e_1_2_9_4_1","volume-title":"Endocarditis Antibiotic Regimens","author":"Tackling G","year":"2020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir842"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-24.5.431"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.6.607"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.3.449"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1376645"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(02)00085-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01064-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.4.299.30941"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-9-200705010-00009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.4.369"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08042.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01471-15"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91834-8"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"351","article-title":"Neutropenia during high dose intravenous oxacillin therapy","volume":"49","author":"Ahern MJ","year":"1976","journal-title":"Yale J Biol Med"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.4.1047-a"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12449"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra066469"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(93)70144-3"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:31:45Z","timestamp":1692988305000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/bcp.15170"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15170","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,28]]}}}