{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:50:40Z","timestamp":1753440640652,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","award":["PHRC2008\u2010 AOR08004"],"award-info":[{"award-number":["PHRC2008\u2010 AOR08004"]}],"id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>The extent of sotalol\u2010induced QTc prolongation on the electrocardiogram, is variable among subjects and influenced by sex. However, the influence of baseline QTc on the extent of drug\u2010induced QTc prolongation remains unclear. This was studied around peak plasma concentration in a large cohort of 376 healthy male and 614 healthy female subjects who received 80\u2009mg of sotalol orally. Baseline QTc was 379\u2009\u00b1\u200916\u2009ms in men and 393\u2009\u00b1\u200915\u2009ms in women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.0001). The change in QTc from baseline was highly variable among both sexes and was greater in women than in men (26.5\u00a0\u00b1\u200913.2 vs.13.0\u00a0\u00b1\u00a010.8\u00a0ms; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.0001). The slope of the regression line between QTc on sotalol and baseline QTc did not significantly differ from unity in men and in women, indicating that the extent of QTc prolongation with sotalol was not influenced by baseline QTc. Assessing QTc after administration of an I<jats:sub>Kr<\/jats:sub> blocker may be more important than measuring a baseline QTc.<\/jats:p>","DOI":"10.1111\/bcp.15188","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T07:14:20Z","timestamp":1639811660000},"page":"3510-3515","source":"Crossref","is-referenced-by-count":2,"title":["Influence of baseline QTc on sotalol\u2010induced prolongation of ventricular repolarization in men and women"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-5189","authenticated-orcid":false,"given":"Christian","family":"Funck\u2010Brentano","sequence":"first","affiliation":[{"name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale (INSERM), Assistance Publique \u2010 H\u00f4pitaux de Paris (AP\u2010HP), Clinical Investigation Center (CIC\u20101901), Department of Pharmacology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne Universit\u00e9  Paris 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