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Multivariable logistic regression analysis was performed adjusting for a wide range of confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of either \u03b2\u2010blockers (BBs), calcium\u2010channel blockers (CCBs) or diuretics was associated with a higher risk of Covid\u201019 hospitalization compared to ACEI use (adjusted OR (95%CI): 1.66 [1.43\u20131.93]) and ARB use (1.53 [1.30\u20131.81]). The risk of 28\u2010day mortality among Covid\u201019 patients was also increased among users of BBs, CCBs or diuretics when compared to ACEI users (1.74 [1.30\u20132.33]) but not when compared to ARB users (1.26 [0.93\u20131.71]). The association between BB, CCB or diuretic use (compared to ACEI use) and 28\u2010day mortality among hospitalized Covid\u201019 patients narrowly missed statistical significance (1.47 [0.99\u20132.18]) but it was statistically significant when the analysis was restricted to patients hospitalized during the second SARS\u2010CoV\u20102 wave (1.80 [1.15\u20132.83]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest protective effects of inhibition of the renin\u2013angiotensin\u2013aldosterone system on Covid\u201019 hospitalization and mortality, particularly with ACEI, among patients with pharmaceutically treated hypertension. If confirmed by randomized controlled trials, this finding could have high clinical relevance for treating hypertension during the SARS\u2010CoV\u20102 pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15192","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T09:37:37Z","timestamp":1640165857000},"page":"2830-2842","source":"Crossref","is-referenced-by-count":6,"title":["Association of renin\u2013angiotensin\u2013aldosterone system inhibition with Covid\u201019 hospitalization and all\u2010cause mortality in the UK biobank"],"prefix":"10.1111","volume":"88","author":[{"given":"Fatemeh","family":"Safizadeh","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center  Heidelberg Germany"},{"name":"Institute for Medical Information Processing, Biometry and Epidemiology\u2010 IBE LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Ngoc Mai","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center  Heidelberg Germany"},{"name":"Network Aging Research University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center  Heidelberg Germany"},{"name":"Network Aging Research University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-4521","authenticated-orcid":false,"given":"Ben","family":"Sch\u00f6ttker","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center  Heidelberg Germany"},{"name":"Network Aging Research University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa097"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.08.039"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.667254"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taaa041"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.510461"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taaa045"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1871"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008975"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2021\/e2342"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2006923"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.052"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_11_16_1","unstructured":"UK Biobank.Facilitating COVID\u201019 research.https:\/\/www.ukbiobank.ac.uk\/enable-your-research\/about-our-data\/covid-19-data. 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