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Recently, it has shown many benefits in modifying the physio\u2010pathological processes occurring upon stimulation of renin\u2013angiotensin\u2013aldosterone system at the ocular level. In CSCR treatment, several clinical studies and case reports prove the efficacy and safety of EPL. However, setbacks for such studies include a relatively small number of participants and short follow\u2010up periods. This review article is intended to describe theories about the nature and classification of CSCR and recapitulate EPL therapeutic benefits as selective mineralocorticoid receptor antagonist in the treatment of CSCR. Furthermore, we survey the literature on clinical studies discussing the results of use of EPL in treatment of CSCR. In addition, EPL therapeutic formulations that have been developed are described, and future potential delivery systems will be suggested.<\/jats:p>","DOI":"10.1111\/bcp.15213","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:33:15Z","timestamp":1641342795000},"page":"2665-2672","source":"Crossref","is-referenced-by-count":5,"title":["Eplerenone repurposing in management of chorioretinopathy: Mechanism, nanomedicine\u2010based delivery applications and future trends"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-3441","authenticated-orcid":false,"given":"Eman","family":"Abdelhakeem","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El\u2010Nabarawi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab","family":"Shamma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.5497\/wjp.v2.i2.47"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.00889.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.130"},{"issue":"12","key":"e_1_2_14_5_1","first-page":"CD011841","article-title":"Interventions for central serous chorioretinopathy: a network meta\u2010analysis","volume":"2015","author":"Salehi M","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02848.x"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090090081024"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30730-6"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090030078043"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080080094039"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.024"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00075-6"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30385-0"},{"issue":"2","key":"e_1_2_14_14_1","first-page":"189","article-title":"Sarcoidosis and central serous retinopathy: a dangerous combination","volume":"15","author":"Sharma OP","year":"1998","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2000.00328.x"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050855"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067219800800110"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-812610"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003470070059"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/08039488.2015.1041156"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02334172"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169099"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00582.x"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30386-2"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)32010-X"},{"issue":"7","key":"e_1_2_14_26_1","first-page":"1035","article-title":"Non\u2010resolving, recurrent and chronic central serous chorioretinopathy: available treatment options","volume":"33","author":"Sartini F","year":"2019","journal-title":"Eye (Basingstoke)"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12097"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S220845"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.07.003"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.05.003"},{"key":"e_1_2_14_31_1","unstructured":"GassDM St LouisCV. 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