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This review summarizes current knowledge on associations between systemic and topical medications and changes in choroidal thickness (CT). This review included 71 studies on mydriatics\/cycloplegics, intraocular pressure (IOP)\u2010lowering therapies, antihypertensives, adrenergic antagonists, statins, corticosteroids, hydroxychloroquine, isotretinoin, hormonal contraceptives, phosphodiesterase inhibitors, antipsychotics, antineoplastic agents, ethanol, caffeine and nicotine. IOP\u2010lowering therapies, atropine eye drops, and systemic administration of \u03b2 blockers and ethanol are associated with a significant increase in CT. Cyclopentolate and phenylephrine are associated with a CT reduction. Systemic medications that decrease CT include caffeine and nicotine. Tropicamide, angiotensin\u2010converting enzyme inhibitors, angiotensin receptor blockers, statins, corticosteroids, hydroxychloroquine and hormonal contraceptives have mixed findings. CT increase associated with IOP\u2010lowering therapies is possibly achieved by enhancing aqueous humour flow to the choroid thus elevating choroidal blood flow and thickness. CT changes appear to be independent from systemic blood pressure changes, suggesting that a significant association with an antihypertensive could be due to an idiosyncratic drug property. Statins and candesartan decrease macrophage accumulation and intercellular adhesion molecule 1 expression in the choroid. The choroid and its response to various disease processes and systemic medication can be further investigated to improve patient care, particularly in patients with choroid and retina pathologies.<\/jats:p>","DOI":"10.1111\/bcp.15237","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T02:05:17Z","timestamp":1642730717000},"page":"2673-2685","source":"Crossref","is-referenced-by-count":20,"title":["The effect of systemic and topical ophthalmic medications on choroidal thickness: A review"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-443X","authenticated-orcid":false,"given":"Shanna C.","family":"Yeung","sequence":"first","affiliation":[{"name":"Faculty of Medicine The University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-7434","authenticated-orcid":false,"given":"Jamie 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