{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:18:10Z","timestamp":1763227090804,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Limited therapeutic options exist for multidrug\u2010resistant\/extensively drug\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>Acinetobacter baumannii<\/jats:italic><\/jats:styled-content> (MDR\/XDR\u2010Ab) meningitis\/ventriculitis. A combination of intravenous and intraventricular (IVT)\/intrathecal (IT) polymyxins achieves good therapeutic outcomes for cases of healthcare\u2010associated MDR\/XDR\u2010Ab meningitis\/ventriculitis. Colistin is commercially available as colistin sulphate and its sulphomethylated derivative. However, the effect and safety of colistin sulphate in the treatment of MDR\/XDR\u2010Ab meningitis\/ventriculitis has not been reported. We report on a 66\u2010year\u2010old male patient who developed post\u2010neurosurgical ventriculitis caused by MDR\u2010Ab. IVT concomitant intravenous colistin sulphate was used as a last\u2010resort antimicrobial therapy, the patient's ventriculitis was dramatically improved, and the concentrations of CSF colistin were higher than the MIC breakpoint throughout the treatment. Meanwhile, no nephrotoxicity or neurotoxicity was observed during the treatment.<\/jats:p>","DOI":"10.1111\/bcp.15238","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T02:06:14Z","timestamp":1642730774000},"page":"3490-3494","source":"Crossref","is-referenced-by-count":10,"title":["Intraventricular colistin sulphate as a last resort therapy in a patient with multidrug\u2010resistant <scp><i>Acinetobacter baumannii<\/i><\/scp> induced post\u2010neurosurgical ventriculitis"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-4519","authenticated-orcid":false,"given":"Xu\u2010Ben","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pharmacy First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit First Affiliated 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