{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:35:25Z","timestamp":1791660925967,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Nocturnal acid breakthrough has been considered an unmet need of proton\u2010pump inhibitors. Tegoprazan, a novel potassium\u2010competitive acid blocker, is expected to show improved properties for this unmet need. This study was aimed to compare night\u2010time acid suppression by tegoprazan with that by vonoprazan or esomeprazole, and to explore the effect of CYP2C19 phenotypes on acid\u2010suppressive effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, open\u2010label, 3\u2010period, 6\u2010sequence crossover study was conducted. A single oral dose of tegoprazan 50\u2009mg, vonoprazan 20\u2009mg or esomeprazole 40\u2009mg was administered at night in each period. Continuous intragastric pH was monitored at baseline and after each dosing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen healthy subjects (6 CYP2C19 extensive metabolizers, 5 intermediate metabolizers, 5 poor metabolizers) completed the study. After a single dose of tegoprazan, intragastric pH increased more rapidly to over 4 at approximately 1\u00a0hour compared to the other treatments, and elevated intragastric pH was maintained stably at night. Tegoprazan exhibited night\u2010time acid suppression for slightly but not significantly longer than vonoprazan, and greater than esomeprazole; % time at pH\u2009\u2265\u20094 at night was 66.0%, 60.5% and 36.1% for tegoprazan, vonoprazan and esomeprazole, respectively. Night\u2010time acid suppression by tegoprazan and vonoprazan was not dependent on CYP2C19 phenotypes, while that by esomeprazole tended to be influenced by CYP2C19 phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tegoprazan produced more rapid, potent and well sustained night\u2010time acid suppression <jats:italic>vs<\/jats:italic>. vonoprazan or esomeprazole when administered at night. Furthermore, tegoprazan showed no CYP2C19 phenotype dependency in acid suppression. It suggests the potential of tegoprazan, especially in preventing nocturnal acid breakthrough.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15268","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:34:43Z","timestamp":1644546883000},"page":"3288-3296","source":"Crossref","is-referenced-by-count":109,"title":["Night\u2010time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-349X","authenticated-orcid":false,"given":"Eunsol","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokuee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Clinical Development HK inno. N Corp.  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Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-7225","authenticated-orcid":false,"given":"Kyung\u2010Sang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SeungHwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of 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