{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:47:51Z","timestamp":1792594071718,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Several cases of herpes zoster (HZ) following mRNA COVID\u201019 vaccination (BNT162b2 and mRNA\u20101273) have been reported, and the first epidemiological evidence suggests an increased risk. We used the worldwide pharmacovigilance database VigiBase to describe HZ cases following mRNA COVID\u201019 vaccination. We performed disproportionality analyses (case\/non\u2010case statistical approach) to assess the relative risk of HZ reporting in mRNA COVID\u201019 vaccine recipients compared to influenza vaccine recipients and according to patient age. To 30 June 2021, of 716\u2009928 reports with mRNA COVID\u201019 vaccines, we found 7728 HZ cases. When compared to influenza vaccines, mRNA COVID\u201019 vaccines were associated with a significantly higher reporting of HZ (reporting odds ratio 1.9, 95% CI 1.8\u20132.1). Furthermore, we found a reduced risk of reporting HZ among under 40\u2010year\u2010old persons compared to older persons (reporting odds ratio 0.39, 95% CI 0.36\u20130.41). Mild and infrequent HZ reactions may occur shortly after mRNA COVID\u201019 vaccination, at higher frequency than reported with influenza vaccination, especially in patients over 40\u2009years old. Further analyses are needed to confirm this risk.<\/jats:p>","DOI":"10.1111\/bcp.15280","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T05:53:43Z","timestamp":1645077223000},"page":"3529-3534","source":"Crossref","is-referenced-by-count":23,"title":["Association study between herpes zoster reporting and mRNA COVID\u201019 vaccines (BNT162b2 and mRNA\u20101273)"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-5925","authenticated-orcid":false,"given":"Laure\u2010H\u00e9l\u00e8ne","family":"Pr\u00e9ta","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie, Centre R\u00e9gional de Pharmacovigilance H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Contejean","sequence":"additional","affiliation":[{"name":"Equipe mobile d'infectiologie H\u00f4pital Cochin  Paris France"},{"name":"Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3210-7171","authenticated-orcid":false,"given":"Francesco","family":"Salvo","sequence":"additional","affiliation":[{"name":"Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology Univ. Bordeaux  Bordeaux France"},{"name":"CHU de Bordeaux Service de Pharmacologie M\u00e9dicale, Centre R\u00e9gional de Pharmacovigilance de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-4742","authenticated-orcid":false,"given":"Jean\u2010Marc","family":"Treluyer","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie, Centre R\u00e9gional de Pharmacovigilance H\u00f4pital Cochin  Paris France"},{"name":"Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Charlier","sequence":"additional","affiliation":[{"name":"Equipe mobile d'infectiologie H\u00f4pital Cochin  Paris France"},{"name":"Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-3571","authenticated-orcid":false,"given":"Laurent","family":"Chouchana","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie, Centre R\u00e9gional de Pharmacovigilance H\u00f4pital Cochin  Paris France"},{"name":"Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102020\u2010003403"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab345"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.092"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20639"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110475"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.01.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.16"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14521"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17646"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00594"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00122"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2021.2219"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2021.03.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010200730100\u201000007"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T14:24:32Z","timestamp":1692714272000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/bcp.15280"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15280","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}