{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:05:01Z","timestamp":1785542701949,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Concomitant use of nonsteroidal anti\u2010inflammatory drugs (NSAIDs) and antithrombotic agents is associated with increased risks of both bleeding and thromboembolism. In this prospective intervention study, community pharmacists screened for NSAID\u2010antithrombotic interactions and contacted the prescribing physician to discuss interaction management. We included 782 interactions; these were found in an older, polymedicated patient population (mean age: 68 y, median of 5 other drugs). Ibuprofen (in 43.0% of cases) and low\u2010dose aspirin (78.8%) were the most frequently involved NSAID and antithrombotic, respectively. Anticoagulants were involved in 16.1% of interaction cases. For 61% of cases, the interacting drugs were prescribed by the same physician. The pharmacist\u2013physician discussion about how to manage the interaction mostly resulted in no change of pharmacotherapy (60.7%); the most frequent reason given by physicians was that the NSAID was for short\u2010term use only. In 39.3% of cases the discussion resulted in a pharmacotherapy change; replacing the NSAID by paracetamol was the most common change.<\/jats:p>","DOI":"10.1111\/bcp.15288","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:49:20Z","timestamp":1645404560000},"page":"3896-3902","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and management of drug interactions between nonsteroidal anti\u2010inflammatory drugs and antithrombotics in ambulatory care"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-208X","authenticated-orcid":false,"given":"Els","family":"Mehuys","sequence":"first","affiliation":[{"name":"Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"De Backer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Centre Ghent University 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