{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:27:56Z","timestamp":1787502476873,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A few studies suggested that epilepsy and antiepileptic drugs with sodium channel\u2010blocking properties were independently associated with out\u2010of\u2010hospital cardiac arrest (OHCA). However, these findings have not yet been replicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using Danish registries, we conducted a nested case\u2013control study in a cohort of individuals between 1 June 2001 and 31 December 2015. Cases were defined as OHCA from presumed cardiac causes, and were matched with non\u2010OHCA\u2010controls based on sex, and age on the date of OHCA. Exposure of interest was epilepsy or antiepileptic drug use. To study the association between individual antiepileptic drug use and the rate of OHCA, we compared each antiepileptic drug with valproic acid. Cox regression with time\u2010dependent covariates was conducted to calculate hazard ratio (HR) and 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 35\u2009195 OHCA\u2010cases and 351\u2009950 matched non\u2010OHCA controls. Epilepsy (cases: 3.58%, controls: 1.60%) was associated with increased rate of OHCA compared with the general population (HR: 1.76, 95%CI: 1.64\u20131.88) when common OHCA risk factors were taken into account. When we studied antiepileptic drug use, we found that 2 antiepileptic drugs without sodium channel blockage, clonazepam (HR: 1.88, 95%CI: 1.45\u20132.44) and pregabalin (HR: 1.33, 95%CI: 1.05\u20131.69), were associated with OHCA, whereas none of the antiepileptic drugs with sodium channel blockage were associated with OHCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Epilepsy is associated with increased rate of OHCA. Our findings do not support a possible association between antiepileptic drugs with sodium channel\u2010blocking properties and OHCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15313","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T05:53:36Z","timestamp":1647410016000},"page":"3709-3715","source":"Crossref","is-referenced-by-count":11,"title":["Risk of out\u2010of\u2010hospital cardiac arrest in patients with epilepsy and users of antiepileptic drugs"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-0068","authenticated-orcid":false,"given":"Talip E.","family":"Eroglu","sequence":"first","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"},{"name":"Department of Experimental and Clinical Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences Amsterdam UMC, Academic Medical Center, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Folke","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"},{"name":"Copenhagen University Hospital \u2013 Copenhagen Emergency Medical Services  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-5818","authenticated-orcid":false,"given":"Hanno L.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences Amsterdam UMC, Academic Medical Center, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Netherlands Heart Institute  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Cardiology Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar H.","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"},{"name":"The Danish Heart Foundation  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"933","volume-title":"Braunwald's heart disease: a textbook of cardiovascular medicine","author":"Myerburg 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