{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:16:24Z","timestamp":1781896584614,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to investigate the effectiveness, safety and pharmacokinetics of adamgammadex in surgical patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight patients aged 18\u201364\u2009years old were randomized to receive adamgammadex (2, 4, 6, and 8\u2009mg.kg<jats:sup>\u22121<\/jats:sup>) or placebo at a ratio of 10:2 for reversal of 0.6\u00a0mg.kg<jats:sup>\u22121<\/jats:sup> rocuronium\u2010induced neuromuscular block. Neuromuscular function was monitored by TOF\u2010Watch\u00ae SX. When the T<jats:sub>2<\/jats:sub> of train\u2010of\u2010four (TOF) reappeared at the end of surgery, patients received an intravenous administration of adamgammadex or placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recovery time of the TOF ratio to 0.9 decreased significantly from 39.3 [29.5, 50.2] minutes in the group that received placebo to 3.0 [2.3, 3.9] minutes, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001; 2.1 [1.5, 3.0] minutes, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001; 2.1 [1.8, 3.3] minutes, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001; and 1.8 [1.5, 2.2] minutes, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001 in the 2, 4, 6 and 8\u00a0mg.kg<jats:sup>\u22121<\/jats:sup> adamgammadex groups, respectively. Then, adamgammadex also showed a shortened recovery time for the TOF ratio recovered to 0.8 and 0.7. Adamgammadex was well tolerated, and no cases of anaphylactic reactions, post\u2010operative bleeding, recurarization, abnormal basic vital signs and prolonged QT intervals were observed. The pharmacokinetics of adamgammadex in plasma increased in dose\u2010dependent manner. The 24\u2010hour cumulative fraction of adamgammadex in urine was 65\u201383%, and that of rocuronium was increased after using adamgammadex from 15% to about 25\u201330%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adamgammadex was found to be effective for reversal of rocuronium\u2010induced neuromuscular block, and it was safe and well tolerated in patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15320","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T12:19:12Z","timestamp":1647692352000},"page":"3760-3770","source":"Crossref","is-referenced-by-count":10,"title":["Adamgammadex in patients to reverse a moderate rocuronium\u2010induced neuromuscular block"],"prefix":"10.1111","volume":"88","author":[{"given":"Ying Ying","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Anesthaesiology, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"National\u2010Local Joint Engineering Research Center of Translational Medicine of Anesthaesiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-5397","authenticated-orcid":false,"given":"Yu Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthaesiology, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Anaesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"National\u2010Local Joint Engineering Research Center of Translational Medicine of Anesthaesiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao Qiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Affiliated Hospital of Zunyi Medical University  Zunyi Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Liuzhou People's Hospital  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Chun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology The Second People's Hospital of Neijiang  Neijiang Sichuan 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