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Every year, an estimated 300\u2009000\u2013500\u2009000 infants, the vast majority of whom are from developing countries, are born with a severe haemoglobin anomaly. Currently, some basic techniques, which include iron chelation therapy, hydroxyurea, blood transfusion, splenectomy and haematopoietic stem cell transplantation, are being used to manage thalassaemia patients. Despite being the backbone of treatment, traditional techniques have several drawbacks and limitations. Ineffective erythropoiesis, correction of globin chain imbalance and adjustment of iron metabolism are some of the innovative treatment methods that have been developed in the care of thalassaemia patients in recent years. Moreover, regulating the expression of B\u2010cell lymphoma\/leukaemia 11A and sex\u2010determining region Y\u2010box through the enhanced expression of micro RNAs can also be considered putative targets for managing haemoglobinopathies. This review focuses on the biological basis of \u03b2\u2010globin gene production, the pathophysiology of \u03b2\u2010thalassaemia and the treatment options that have recently been introduced.<\/jats:p>","DOI":"10.1111\/bcp.15343","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T21:08:56Z","timestamp":1649020136000},"page":"3610-3626","source":"Crossref","is-referenced-by-count":26,"title":["Beta\u2010thalassemia and the advent of new interventions beyond transfusion and iron chelation"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-8406","authenticated-orcid":false,"given":"Waseem","family":"Chauhan","sequence":"first","affiliation":[{"name":"Human Genetics and Toxicology Laboratory, Department of Zoology Aligarh Muslim University  Aligarh 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