{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:18:46Z","timestamp":1788081526677,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>It is not clear if platelet responses are sustained after thrombopoietin receptor agonist (ar\u2010TPO) withdrawal in paediatric patients. A multicentre retrospective observational study was performed in children with chronic immune thrombopenia (cITP) to describe ar\u2010TPO tapering and withdrawal in patients who had achieved a sustained complete response to ar\u2010TPOs. Ten patients (eltrombopag n\u2009=\u20096, romiplostim n\u2009=\u20094) were included. Treatment withdrawal was performed after a mean tapering time of 7.6\u00a0months. Two patients relapsed (median follow\u2010up time of 24\u2009months). Slow tapering and withdrawal of ar\u2010TPOs can be safely performed in cITP paediatric patients after achieving a sustained complete response.<\/jats:p>","DOI":"10.1111\/bcp.15378","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T04:04:30Z","timestamp":1651464270000},"page":"4220-4223","source":"Crossref","is-referenced-by-count":3,"title":["Tapering of the thrombopoietin receptor agonist in paediatric patients with chronic immune thrombocytopenia: Is it possible?"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-5889","authenticated-orcid":false,"given":"Mar\u00eda","family":"Solsona","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda Pedi\u00e1trica Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-7489","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Berrueco","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Pedi\u00e1trica Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Grupo trabajo de la PTI de la Sociedad Espa\u00f1ola de Hematolog\u00eda y Oncolog\u00eda Pedi\u00e1tricas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Grupo trabajo de la PTI de la Sociedad Espa\u00f1ola de Hematolog\u00eda y Oncolog\u00eda Pedi\u00e1tricas"},{"name":"Servicio de Hematolog\u00eda Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1urea","family":"Cervera","sequence":"additional","affiliation":[{"name":"Grupo trabajo de la PTI de la Sociedad Espa\u00f1ola de Hematolog\u00eda y Oncolog\u00eda Pedi\u00e1tricas"},{"name":"Servicio de Pediatr\u00eda Hospital Universitario de M\u00f3stoles  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sastre","sequence":"additional","affiliation":[{"name":"Grupo trabajo de la PTI de la Sociedad Espa\u00f1ola de Hematolog\u00eda y Oncolog\u00eda Pedi\u00e1tricas"},{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda Pedi\u00e1tricas Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Astigarraga","sequence":"additional","affiliation":[{"name":"Grupo trabajo de la PTI de la Sociedad Espa\u00f1ola de Hematolog\u00eda y Oncolog\u00eda Pedi\u00e1tricas"},{"name":"Servicio de Pediatr\u00eda Hospital Universitario Cruces. 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