{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:44:44Z","timestamp":1793108684224,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This systematic review aims to assess the safety profile of oxcarbazepine during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational studies that included women who took oxcarbazepine anytime during pregnancy were included in our systematic review. The review did not include non\u2010English articles, reviews, meta\u2010analyses, case reports and animal studies. Different online sources such as MEDLINE, Cochrane library, Virtual Health Library, etc., were searched for published and unpublished literature. Assessment of the risk of bias in observational studies was carried out using the Newcastle\u2010Ottawa Scale. The meta\u2010analyses were performed using a random\u2010effect model. GRADE was used for the evaluation of the quality of evidence for the primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 19 cohort studies with a total of 5\u2009071\u2009137 patients, of which 2450 were exposed to oxcarbazepine either as monotherapy or polytherapy. The summary odds ratio (OR) was 1.69 (95% CI, 0.95\u20132.98) for congenital malformations following in\u2010utero exposure to oxcarbazepine as compared to the control group of unexposed patients (seven studies [<jats:italic>n<\/jats:italic>\u2009=\u2009625]), and was 1.19 (95% CI, 0.67\u20132.12) when compared to those following lamotrigine (LTG) exposure during pregnancy (3 studies [<jats:italic>n<\/jats:italic>\u2009=\u2009591]). In total, three studies (<jats:italic>n<\/jats:italic>\u2009=\u2009770) reported the association between in\u2010utero oxcarbazepine exposure and fetal\/perinatal deaths. The meta\u2010analysis yielded a summary OR of 3.33 (95% CI, 1.70\u20136.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our systematic review will help healthcare providers and guideline developers regarding the treatment of epilepsy and other neurological disorders during pregnancy. More cohort studies with a higher sample size concerning oxcarbazepine use in pregnant patients are required to truly assess the in\u2010utero safety profile of the drug.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15413","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T06:04:13Z","timestamp":1653026653000},"page":"3600-3609","source":"Crossref","is-referenced-by-count":8,"title":["Adverse fetal and neonatal outcomes following in\u2010utero exposure to oxcarbazepine: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"88","author":[{"given":"Farwa","family":"Athar","sequence":"first","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-2342","authenticated-orcid":false,"given":"Muhammad","family":"Ehsan","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minaam","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin B.","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Medicine Einstein Medical Center  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-7137","authenticated-orcid":false,"given":"Huzaifa A.","family":"Cheema","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzaib","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Naveed","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Umer","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Epilepsy.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/epilepsy. 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