{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:58:18Z","timestamp":1762642698982,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Esomeprazole is a proton pump inhibitor being investigated for treatment of preeclampsia. Esomeprazole pharmacokinetics during pregnancy are unknown. We used data from 10 pregnant participants with preterm preeclampsia, and 49 non\u2010pregnant participants to develop a population pharmacokinetic model of esomeprazole. A two\u2010compartment model described the data well. In pregnant participants after single dose, clearance was 42.2% (14.9\u201361.6%) lower compared to non\u2010pregnant, most likely due to inhibition of CYP2C19. In non\u2010pregnant participants after repeated dosing, clearance was 54.9% (48.2\u201363.5%) lower in extensive metabolizers and bioavailability was 33% (10.0\u201352.0%) higher compared to single dosing, which could be due to autoinhibition of CYP2C19. During pregnancy, the CYP2C19 autoinhibition effect with repeated dosing is expected to lead to much lower increase in exposure compared to non\u2010pregnant individuals, since CYP2C19 is already inhibited due to pregnancy.<\/jats:p>","DOI":"10.1111\/bcp.15416","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T06:31:23Z","timestamp":1653287483000},"page":"4639-4645","source":"Crossref","is-referenced-by-count":2,"title":["Population pharmacokinetics of esomeprazole in patients with preterm preeclampsia"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-093X","authenticated-orcid":false,"given":"Manna Semere","family":"Gebreyesus","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-5150","authenticated-orcid":false,"given":"Eric H.","family":"Decloedt","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine Stellenbosch University and Tygerberg Hospital  Stellenbosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-8964","authenticated-orcid":false,"given":"Catherine A.","family":"Cluver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Stellenbosch University and Tygerberg Hospital  Stellenbosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-7028","authenticated-orcid":false,"given":"Nicole G. 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