{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:56:41Z","timestamp":1787165801381,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["03"],"award-info":[{"award-number":["03"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073671"],"award-info":[{"award-number":["82073671"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Residual neuromuscular blockade is a common complication after general anaesthesia. Sugammadex can reverse the action of aminosteroid neuromuscular blockers. This study aimed to explore sugammadex safety issues in the real world and determine the spectrum of adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All sugammadex\u2010related adverse events reported in VigiBase between 2010 and 2019 were classified by group queries according to the Medical Dictionary for Regulatory Activities. A disproportionality analysis of data was performed using the information component (IC); positive IC values were deemed significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 16\u2009219\u2009410 adverse events were reported and 2032 were associated with sugammadex. The frequent reactions were recurrence of neuromuscular blockade (n\u2009=\u200954, IC 6.74, IC\n                      <jats:sub>025<\/jats:sub>\n                      6.33), laryngospasm (n\u2009=\u200953, IC 6.05, IC\n                      <jats:sub>025<\/jats:sub>\n                      5.64), bronchospasm (n\u2009=\u2009119, IC 5.63, IC\n                      <jats:sub>025<\/jats:sub>\n                      5.36) and bradycardia (n\u2009=\u2009169, IC 5.13, IC\n                      <jats:sub>025<\/jats:sub>\n                      4.90). Fatal cases were more likely among patients with cardiac disorders, especially those over 65\u2009years. In addition, the common adverse drug reactions (ADRs) differed between different age groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). ADRs were higher in the 0\u201017\u2009years age group than in other age groups. The onset time of common ADRs was typically within 1\u00a0day and 68.9% occurred within half an hour after sugammadex administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anaesthesiologists should carefully monitor the anaesthesia recovery period to correct the ADRs caused by sugammadex and recommend monitoring neuromuscular function throughout the anaesthesia process. Sugammadex should be used carefully in patients with cardiovascular diseases, and electrocardiography and hemodynamic changes should be monitored after medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15417","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T04:58:00Z","timestamp":1653368280000},"page":"449-457","source":"Crossref","is-referenced-by-count":7,"title":["Safety of sugammadex for reversal of neuromuscular block: A postmarketing study based on the World Health Organization pharmacovigilance database"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-3955","authenticated-orcid":false,"given":"Qiang","family":"Lyu","sequence":"first","affiliation":[{"name":"Basic Medical College Naval Medical University  Shanghai China"},{"name":"92608 Militang Hospital of PLA  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Huadong Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Health Statistics, Faculty of Health Service Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Health Statistics, Faculty of Health Service Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-9434","authenticated-orcid":false,"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Health Statistics, Faculty of Health Service Naval Medical 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