{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:54:05Z","timestamp":1768694045047,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse drug\u2010induced reaction. Commonly related to anticonvulsant and allopurinol, DRESS can affect both adults and children. Cefotaxime is rarely associated with DRESS, especially with children. We report a cefotaxime\u2010induced DRESS in a child and emphasize the role of allergological work\u2010up to point out the culprit drug in exploring cross\u2010reactivity and identifying a possible cosensitization. A 2\u2010year\u2010old boy was treated with cefotaxime, vancomycin and metronidazole for acute otomastoiditis. Metronidazole was withdrawn and vancomycin was changed by teicoplanin 10 and 15\u2009days later, respectively. Nineteen days after ongoing cefotaxime and 4 days after teicoplanin intake, the patient developed hyperthermia, a widespread exanthema, facial oedema with neither mucosal involvement nor palpable lymphadenopathy. Biological tests revealed eosinophilia, atypical lymphocytes, mild cytolysis and a high lactate dehydrogenase level. Serological tests for viral and bacterial infections were negative. DRESS was suspected and the 2 antibiotics were withdrawn. Intradermal tests (IDT) were carried out 2 months later with cefotaxime and teicoplanin. They revealed a positive result at 48\u2010hour reading. To assess cross\u2010reactivity among \u03b2\u2010lactams, IDT to penicillins (benzylpenicillin, amoxicillin and oxacillin) was performed showing negative results at 48\u2010hour reading. Nevertheless, IDT to cephalosporins (cefazolin, cefuroxime, ceftazidime and ceftriaxone) displayed positive results at 48\u2010hour reading. As a result, IDT are of great interest and should be performed to confirm the role of cefotaxime and detect a potential cross\u2010reactivity with chemically similar drugs and drugs taken before and during the episode of DRESS.<\/jats:p>","DOI":"10.1111\/bcp.15419","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T01:58:39Z","timestamp":1653443919000},"page":"544-550","source":"Crossref","is-referenced-by-count":10,"title":["Cefotaxime\u2010induced drug reaction with eosinophilia and systemic symptom in a child with cross\u2010reactivity to other cephalosporins and cosensitization to teicoplanin"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-1102","authenticated-orcid":false,"given":"Khadija","family":"Mansour","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine University of Monastir  Monastir 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