{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:54:09Z","timestamp":1789404849119,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>The study aim was to assess the abuse\/misuse potential of second\u2010generation antipsychotics (SGAPs) using VigiBase data. We extracted individual case safety reports of \u201cDrug abuse, dependence and withdrawal\u201d involving SGAPs up to June 2018. We assessed disproportionate reporting by calculating the information component, considering the lower end of the 95% credibility interval for the information component (IC<jats:sub>025<\/jats:sub>), and the proportional reporting ratio. We identified 1683 individual case safety reports recorded as \u201cabuse, dependence and withdrawal\u201d involving SGAPs, mainly quetiapine (<jats:italic>n\u2009=<\/jats:italic>\u00a01089) and olanzapine (<jats:italic>n\u2009=<\/jats:italic>\u00a0209). The disproportional reporting indicators highlighted an association between \u201cDrug abuse and dependence\u201d, and quetiapine, olanzapine and ziprasidone, as indicated by the IC<jats:sub>025<\/jats:sub> (2.263, 0.259 and 1.051, respectively) and proportional reporting ratio values (3.929, 1.020 and 1.334, respectively). The abuse\/misuse potential is confirmed for quetiapine and olanzapine and highlighted for the first time for ziprasidone. Physicians should consider these risks when prescribing these antipsychotics, especially to patients with history of drug abuse.<\/jats:p>","DOI":"10.1111\/bcp.15420","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T05:24:14Z","timestamp":1653715454000},"page":"4646-4653","source":"Crossref","is-referenced-by-count":18,"title":["Abuse and misuse of second\u2010generation antipsychotics: An analysis using VigiBase, the World Health Organisation pharmacovigilance database"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-8834","authenticated-orcid":false,"given":"Sophie","family":"Roy","sequence":"first","affiliation":[{"name":"Addictovigilance Centre Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Charreteur","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Peries","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic Infections University of Montpellier, INSERM, EFS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Kheloufi","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre, Department of Clinical Pharmacology and Pharmacovigilance University of Aix Marseille, INSERM UMR 1106 Institut de Neurosciences des Syst\u00e8mes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9811","authenticated-orcid":false,"given":"C\u00e9line","family":"Eiden","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Nagot","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic Infections University of Montpellier, INSERM, EFS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-812X","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Donnadieu\u2010Rigole","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic Infections University of Montpellier, INSERM, EFS  Montpellier France"},{"name":"Department of Addictology Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-7835","authenticated-orcid":false,"given":"Jo\u00eblle","family":"Micallef","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre, Department of Clinical Pharmacology and Pharmacovigilance University of Aix Marseille, INSERM UMR 1106 Institut de Neurosciences des Syst\u00e8mes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-9099","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Peyri\u00e8re","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre Montpellier University Hospital  Montpellier France"},{"name":"Pathogenesis and Control of Chronic Infections University of Montpellier, INSERM, EFS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010017\u20102406\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.7.841"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8040073"},{"issue":"6","key":"e_1_2_11_5_1","first-page":"13","article-title":"Is seroquel developing an illicit reputation for misuse\/abuse?","volume":"7","author":"Sansone RA","year":"2010","journal-title":"Psychiatry"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10100736"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4137\/SART.S22233"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113168"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000814"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178221819844205"},{"key":"e_1_2_11_11_1","unstructured":"VigiBase.Uppsala Monitoring Centre [Internet]. 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