{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:04:14Z","timestamp":1774343054084,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Although the benefit\/risk profile for mRNA COVID\u201019 vaccines is recognised as extremely favourable, appendicitis is currently considered an adverse event (AE) of special interest. We describe the case of a 58\u2010year\u2010old female who presented with signs and symptoms of appendicitis approximately 48\u2009hours after her first injection of the Pfizer\u2010BioNTech vaccine. Abdominal ultrasound revealed fluid collection in the right iliac fossa and cecal wall thickening. Following the surgical visit, CT scan with contrast showed a distended appendix with thickened walls, suggestive of acute appendicitis. The patient tested negative to upper respiratory COVID\u201019 reverse transcription\u2010polymerase chain reaction. Clinical trials and observational studies suggest a possible association between appendicitis and COVID\u201019 vaccines. Th\u20101 driven granulomatous inflammation reported in our case represents an infrequent nonspecific chronic inflammation of the appendix, especially in the setting of delayed or interval appendectomy. In view of the current paediatric vaccination campaign, we recommend monitoring the safety profile and potential gastrointestinal AEs associated with mRNA COVID\u201019 vaccines to swiftly manage subjects with gastrointestinal symptoms and prevent potential complications.<\/jats:p>","DOI":"10.1111\/bcp.15421","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T06:58:45Z","timestamp":1653721125000},"page":"551-555","source":"Crossref","is-referenced-by-count":7,"title":["Acute appendicitis in a patient immunised with COVID\u201019 vaccine: A case report with morphological analysis"],"prefix":"10.1111","volume":"89","author":[{"given":"Ettore","family":"Marconi","sequence":"first","affiliation":[{"name":"Health Search Italian College of General Practitioners and Primary Care  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Crescioli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence  Florence Italy"},{"name":"Tuscan Regional Centre of Pharmacovigilance  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Bonaiuti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Histopathology and Molecular Diagnostics, Careggi Teaching Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Santi","sequence":"additional","affiliation":[{"name":"Pathology Section, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Nesi","sequence":"additional","affiliation":[{"name":"Pathology Section, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Cerbai","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-2026","authenticated-orcid":false,"given":"Alfredo","family":"Vannacci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence  Florence Italy"},{"name":"Tuscan Regional Centre of Pharmacovigilance  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence  Florence Italy"},{"name":"Tuscan Regional Centre of Pharmacovigilance  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Our World In Data.Coronavirus (COVID\u201019) Vaccinations. 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