{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:53:15Z","timestamp":1794441195719,"version":"4.9.1"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>A recent review identified 19 anticholinergic burden scales (ABSs) but no study has yet compared the impact of all 19 ABSs on delirium. We evaluated whether a high anticholinergic burden as classified by each ABS is associated with incident delirium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a retrospective cohort study in a Swiss tertiary teaching hospital using data from 2015\u20132018. Included were patients aged \u226565, hospitalised \u226548\u2009hours with no stay &gt;24\u2009hours in intensive care. Delirium was defined twofold: (i) ICD\u201010 or CAM and (ii) ICD\u201010 or CAM or DOSS. Patients' cumulative anticholinergic burden score, calculated within 24\u2009hours after admission, was classified using a binary (&lt;3: low, \u22653: high burden) and a categorical approach (0: no, 0.5\u20133: low, \u22653: high burden). Association was analysed using multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 25\u2009000 patients (mean age 77.9\u2009\u00b1\u20097.6\u00a0years) were included. Of these, (i) 864 (3.3%) and (ii) 2770 (11.0%) developed delirium. Depending on the evaluated ABS, 4\u201363% of the patients were exposed to at least one anticholinergic drug. Out of 19 ABSs, (i) 14 and (ii) 16 showed a significant association with the outcomes. A patient with a high anticholinergic burden score had odds ratios (ORs) of 1.21 (95% confidence interval [CI]: 1.03\u20131.42) to 2.63 (95% CI: 2.28\u20133.03) for incident delirium compared to those with low or no burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high anticholinergic burden within 24\u2009hours after admission was significantly associated with incident delirium. Although prospective studies need to confirm these results, discontinuing or substituting drugs with a score of \u22653 at admission might be a targeted intervention to reduce incident delirium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15432","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T15:39:29Z","timestamp":1654702769000},"page":"4915-4927","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients \u2013 A cohort study comparing 19 anticholinergic burden scales"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-492X","authenticated-orcid":false,"given":"Angela","family":"Lisibach","sequence":"first","affiliation":[{"name":"Clinical Pharmacy, Department Medical Services Cantonal Hospital of Baden  Baden Switzerland"},{"name":"Center for Research and Innovation in Clinical Pharmaceutical Sciences 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