{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:02:47Z","timestamp":1792105367240,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the gabapentinoid\u2013oedema\u2013loop diuretic prescribing cascade in adults using large administrative health care databases from the USA and Denmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study used a sequence symmetry analysis to assess loop diuretic initiation before and after the initiation of gabapentinoids among patients aged 20\u2009years or older without heart failure or chronic kidney disease. Data from MarketScan Commercial and Medicare Supplemental Claims databases (2005 to 2019) and Danish National Prescription Register (2005 to 2018) were analyzed. Use of loop diuretics associated with initiation of selective norepinephrine reuptake inhibitors (SNRI) was used as a negative control. We assessed the pooled temporality of loop diuretic initiation relative to gabapentinoid or SNRI initiation across the 2 countries. Secular trend\u2010adjusted sequence ratios (aSRs) with 95% confidence intervals (CIs) were calculated using data from 90\u2009days before and after initiation of gabapentinoids. Pooled ratio of aSRs were calculated by comparing gabapentinoids to SNRIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 1\u2009511\u2009493 gabapentinoid initiators (Denmark [<jats:italic>n<\/jats:italic>\u00a0=\u2009338\u2009941]; USA [<jats:italic>n<\/jats:italic>\u00a0=\u20091\u2009172\u2009552]), 20\u2009139 patients had a new loop diuretic prescription 90\u2009days before or after gabapentinoid initiation, resulting in a pooled aSR of 1.33 (95% CI 1.06\u20131.67). The pooled aSR for the negative control (i.e., SNRI) was 0.84 (95% CI 0.75\u20130.94), which resulted in a pooled ratio of aSRs of 1.58 (95% CI 1.23\u20132.04). Pooled estimated incidence of the gabapentinoid\u2013loop diuretic prescribing cascade was 8.14 (95% CI, 1.92\u201334.49) events per 1000 patient\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified evidence of the gabapentinoid\u2013oedema\u2013loop diuretic prescribing cascade in 2 countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15447","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T09:29:23Z","timestamp":1656062963000},"page":"5269-5294","source":"Crossref","is-referenced-by-count":10,"title":["Association between gabapentinoids and oedema treated with loop diuretics: A pooled sequence symmetry analysis from the USA and Denmark"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-2160","authenticated-orcid":false,"given":"Scott Martin","family":"Vouri","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Outcomes &amp; Policy University of Florida College of Pharmacy  Gainesville Florida USA"},{"name":"Center for Drug Evaluation and Safety University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6092-8906","authenticated-orcid":false,"given":"Earl J.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes &amp; Policy University of Florida College of Pharmacy  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Hsin\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes &amp; Policy University of Florida College of Pharmacy  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa","family":"Hashim Jaber Bilal","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-8708","authenticated-orcid":false,"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Odense University Hospital  Odense Denmark"},{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-6195","authenticated-orcid":false,"given":"Daniel Pilsgaard","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Odense University Hospital  Odense Denmark"},{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.057"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00228"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010083"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12358"},{"key":"e_1_2_11_6_1","unstructured":"Food U Administration D.FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin. 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