{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:04Z","timestamp":1787013904187,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["09\/0003886"],"award-info":[{"award-number":["09\/0003886"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Active vitamin D deficiency is associated with increased aortic\u2010pulse wave velocity (Ao\u2010PWV) in people with type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active vitamin D treatment on Ao\u2010PWV in people with T2DM and CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 48\u2010week duration single\u2010centre randomised double\u2010blind parallel\u2010group trial examined the impact of oral 1,25 dihydroxyvitamin D (calcitriol 0.25\u2009mcg\u2009OD) as compared to placebo on a primary endpoint of Ao\u2010PWV. People with T2DM and stable stage 3 CKD with intact parathyroid hormone (iPTH) level &gt;30\u2009pg\/mL were eligible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 127 (70% male) people were randomised (calcitriol\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200964 or placebo\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963). There was no change in Ao\u2010PWV observed, mean \u00b1 standard deviation (SD), in the calcitriol group of 11.79 (\u00b12.5) to 12.08 (3.0) m\/s as compared to 10.90 (\u00b12.4) to 11.39 (\u00b12.6) m\/s with placebo. The between\u2010treatment group adjusted mean (95% confidence interval [(CI]] change was 0.23 (\u22120.58 to 1.05) m\/s,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.57. No effect of calcitriol was observed on central arterial pressures, albuminuria, serum calcium or phosphate levels. However, iPTH fell with calcitriol treatment (mean [95% CI] between\u2010group difference of \u221227.8 (\u221242.3 to \u221213.2) pg\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In T2DM and stage 3 CKD, calcitriol as compared to placebo does not improve Ao\u2010PWV or other markers of arterial stiffness. Our study does not provide evidence for the use of active vitamin D for improving arterial stiffness in T2DM with stage 3 CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15484","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T04:13:21Z","timestamp":1660018401000},"page":"279-289","source":"Crossref","is-referenced-by-count":9,"title":["Effect of calcitriol treatment on arterial stiffness in people with type 2 diabetes and stage 3 chronic kidney disease"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-8320","authenticated-orcid":false,"given":"Janaka","family":"Karalliedde","sequence":"first","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine and Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Fountoulakis","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and 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London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Mangelis","sequence":"additional","affiliation":[{"name":"School of Population Health &amp; Environmental Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Panagiotou","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine and Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Ayis","sequence":"additional","affiliation":[{"name":"School of Population Health &amp; Environmental Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thomas","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine and Sciences King's College London  London 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