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The skin is the organ most frequently affected by drug reactions, which may affect up to 10% of hospitalized patients and occur in 1\u20133% of multimedicated patients. Most CADRs are mild or self\u2010resolving conditions; however, 2\u20136.7% of could develop into potentially life\u2010threatening conditions. CADRs represent a heterogeneous field and can be diagnostically challenging as they may potentially mimic any dermatosis. Currently, there are between 29\u201335 different cutaneous drug\u2010reaction patterns reported ranging from mild dermatitis to an extensively burnt patient. The most frequently reported are maculopapular rash, urticaria\/angioedema, fixed drug eruption and erythema multiforme. Less common but more severe patterns include erythroderma, drug reaction with eosinophilia and systemic symptoms, and Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis spectrum. Almost any drug can induce a CADR, but antibiotics, nonsteroidal anti\u2010inflammatory drugs and antiepileptics are the most frequently involved. Different mechanisms are involved in the pathogenesis of CADRs, although in some cases, these remain still unknown. CADRs could be classified in different ways: (i) type A (augmented) or type B (bizarre); (ii) immediate or delayed; (iii) immune\u2010mediated or nonimmune\u2010mediated; (iv) nonsevere or life\u2010threatening; and (v) by their phenotype, including exanthematous, urticarial, pustular and blistering morphology. 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