{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:35:32Z","timestamp":1771918532642,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018534","name":"Medical Innovation Project of Fujian Province","doi-asserted-by":"publisher","award":["2019\u2010CX\u201019"],"award-info":[{"award-number":["2019\u2010CX\u201019"]}],"id":[{"id":"10.13039\/501100018534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to identify factors associated with gastrointestinal bleeding (GIB) in patients on direct oral anticoagulants (DOACs) and develop a risk score that would provide an effective tool for the clinical assessment of GIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicentre retrospective analysis of clinical and follow\u2010up data of patients treated with DOACs. The score was developed through logistic regression. The performance of score was evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, specificity and Hosmer\u2013Lemeshow test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 11\u2009903 patients had a mean age of 65.1\u00a0years. In multivariate analysis, age \u226565\u2009years, alcohol use, history of peptic ulcer, history of major bleeding, abnormal liver function or renal function, cancer, platelet count &lt;100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, anaemia, and concurrent antiplatelet agent or non\u2010steroidal anti\u2010inflammatory drug treatment were independent risk factors for GIB, and concurrent treatment with gastrointestinal protective agents were a protective factor. The Alfalfa\u2010DOAC\u2010GIB score was constructed using these 12 factors. The AUC of the Alfalfa\u2010DOAC\u2010GIB score was 0.77 (95% CI 0.74\u20130.81), which was higher than that of the HAS\u2010BLED score (0.69; 95% CI 0.65\u20130.72) and the New score (0.65; 95% CI 0.61\u20130.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on 12 factors, we developed a gastrointestinal bleeding risk score. The newly developed Alfalfa\u2010DOAC\u2010GIB score has better predictive value than the HAS\u2010BLED score and the New score, and might be an effective tool to help reduce the occurrence of GIB in patients using DOACs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15491","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T07:25:24Z","timestamp":1660634724000},"page":"253-260","source":"Crossref","is-referenced-by-count":12,"title":["A new model to predict the risk of major gastrointestinal bleeding in patients on direct oral anticoagulants (dabigatran and rivaroxaban)"],"prefix":"10.1111","volume":"89","author":[{"given":"Meina","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Fujian Provincial Maternity and Children's Hospital Affiliated Hospital of Fujian Medical University  Fujian 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