{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:55:53Z","timestamp":1791780953715,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302305"],"award-info":[{"award-number":["81302305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009812","name":"Chinese Society of Clinical Oncology","doi-asserted-by":"publisher","award":["Y\u2010SY201901\u20100168"],"award-info":[{"award-number":["Y\u2010SY201901\u20100168"]}],"id":[{"id":"10.13039\/501100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009812","name":"Chinese Society of Clinical Oncology","doi-asserted-by":"publisher","award":["Y\u2010sy2018\u2010077"],"award-info":[{"award-number":["Y\u2010sy2018\u2010077"]}],"id":[{"id":"10.13039\/501100009812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>As one of the mainstays of breast cancer therapy, chemotherapy inevitably induces neutropenia. In this study, we explored the role of PEG\u2010rhG\u2010CSF (pegylated recombinant human granulocyte colony\u2010stimulating factor) in the emergency treatment of chemotherapy\u2010induced grades 3\u20134 neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 patients with breast cancer were randomized (1:1) into the study. Fifty patients randomized to the experimental group were treated with PEG\u2010rhG\u2010CSF after grades 3\u20134 neutropenia following the first cycle of chemotherapy, while 50 patients randomized to the control group received a daily injection of rhG\u2010CSF (recombinant human granulocyte colony\u2010stimulating factor). The primary endpoint was the recovery time of grades 3\u20134 neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with patients in the control group, the mean \u00b1 SD recovery time of grades 3\u20134 neutropenia and febrile neutropenia (FN) was significantly shorter for patients in the experimental group (grades 3\u20134, <jats:italic>P<\/jats:italic>\u2009=\u2009.000; grade 4, <jats:italic>P<\/jats:italic>\u2009=\u2009.000; FN, <jats:italic>P<\/jats:italic>\u2009=\u2009.038). There is no significant difference in the incidence of FN for the two groups. In the experimental group, the duration of grades 3\u20134 neutropenia in patients aged &lt;60\u2009years and \u226560\u2009years was 2.15 and 3.20\u2009days, respectively (<jats:italic>P<\/jats:italic>\u2009=\u2009.037). Adverse events (AEs) of any grade were reported in 37 (75.5%) and 28 (59.6%) patients from the two groups, respectively. No grade \u22653 AEs were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study supported that the PEG\u2010rhG\u2010CSF was more effective and convenient than rhG\u2010CSF for treating grades 3\u20134 neutropenia and FN in patients with breast cancer and had manageable toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15507","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T14:27:59Z","timestamp":1661351279000},"page":"372-379","source":"Crossref","is-referenced-by-count":9,"title":["A prospective, randomized clinical trial of emergency treatment of chemotherapy\u2010induced neutropenia and febrile neutropenia by pegylated recombinant human granulocyte colony\u2010stimulating factor (PEG\u2010rhG\u2010CSF)"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-3653","authenticated-orcid":false,"given":"Xiaofeng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Huai'an First People's Hospital Nanjing Medical University  Huai'an Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinggang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Disease the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304\u2010017\u20100424\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S157058"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010019\u20100828\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020189"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015\u20100152"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000715"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155215625459"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146817"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.838558"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2017.05.04"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901101)66:9<1904::AID-CNCR2820660908>3.0.CO;2-V"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.11.2849.2849"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.4.1303.1303"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102972"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.6319"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_463_17"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.2160"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016\u20100011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2015.12.002"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010017\u20103842\u20101"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586040\u2010000000000\u201000000"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.06.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201009\u20100761"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010017\u20104609\u20106"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm438"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4118"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010020\u201004749\u20106"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.21.00154"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.20.01091"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114079"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010006\u20100201\u2010z"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15507","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:20:59Z","timestamp":1692444059000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/bcp.15507"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15507","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]}}}