{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:42:06Z","timestamp":1773070926706,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to assess clinical efficacy of ceftazidime\u2013avibactam for the management of carbapenem\u2010resistant Gram\u2010negative infections in renal patients receiving recommended dosing adjustments compared to those treated with scheduled full\u2010dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two authors independently searched PubMed\u2010MEDLINE and Scopus database from inception to 31 December 2021, to retrieve randomized controlled trials or observational studies comparing clinical efficacy of ceftazidime\u2013avibactam in patients affected by carbapenem\u2010resistant Gram\u2010negative infections receiving recommended renal dosing adjustments compared to those treated with scheduled full\u2010dose. Data were independently extracted by the 2 authors, and the quality of included studies was independently assessed according to ROBINS\u2010I tool for observational studies. Mortality rate was selected as primary outcome. Meta\u2010analysis was conducted by including only studies at low or moderate risk of bias providing adjustment for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1794 articles were screened, and 11 observational studies (1 prospective and 10 retrospective) were included. Serious or critical risk of bias was found in 4 studies, while the other 7 were classified at moderate risk of bias and included in the meta\u2010analysis. Renal dosing adjustments of ceftazidime\u2013avibactam were associated with higher risk of mortality (odds ratio 1.79; 95% confidence interval 1.18\u20132.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Renal dosing adjustment of ceftazidime\u2013avibactam seems to be associated with a higher risk of mortality in patients affected by carbapenem\u2010resistant Gram\u2010negative infections. However, residual confounder associated with baseline conditions cannot be excluded. Further prospective studies including larger samples are warranted to definitively address this unmet clinical need.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15586","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T08:59:37Z","timestamp":1667811577000},"page":"617-629","source":"Crossref","is-referenced-by-count":15,"title":["Clinical efficacy of renal dosing adjustments of ceftazidime\u2013avibactam in patients affected by carbapenem\u2010resistant Gram\u2010negative infections: A systematic review and meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3018-3779","authenticated-orcid":false,"given":"Milo","family":"Gatti","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna  Bologna Italy"},{"name":"Clinical Pharmacology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna 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