{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:50:45Z","timestamp":1768283445246,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Few studies have investigated linezolid (LZD)\u2010associated cardiotoxicity. This study explored the potential association between LZD and QT interval prolongation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adverse event reports of QT interval prolongation associated with LZD from the Food and Drug Administration Adverse Event Reporting System from January 2013 to December 2021 were analysed and the reporting odds ratio (ROR) with 95% confidence intervals were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6738 adverse event reports of LZD as the primary and secondary suspected drug were obtained from the database, including 192 reports with electrocardiogram QT prolonged (QTp), and the ROR value was 26.1 (95% CI\u2009=\u200922.6\u201330.2). There were 8 reports of long QT syndrome, ROR 14.2 (95% CI\u2009=\u00a07.1\u201328.5); 5 reports of torsade de pointes, ROR 3.2 (95% CI\u2009=\u00a01.3\u20137.6); and 5 reports of ventricular tachycardia, ROR 1.9 (95% CI\u2009=\u00a00.8\u20134.5). Subgroup analysis revealed that patients with tuberculosis treated with LZD had a higher reporting rate among all QTp reports, exhibiting an odds ratio of 330.0 (95% CI\u2009=\u2009223.1\u2013488.1). The odds ratios of QTp associated with LZD treatments in patients with and without tuberculosis were 4.2 (95% CI\u2009=\u00a03.4\u20135.3) and 1.2 (95% CI\u2009=\u00a00.8\u20131.6), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study showed an association between LZD and QT interval prolongation. In the report on patients with tuberculosis, the incidence of QTp was higher when treated with LZD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15587","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T19:28:31Z","timestamp":1667935711000},"page":"1386-1392","source":"Crossref","is-referenced-by-count":6,"title":["Linezolid and the risk of QT interval prolongation: A pharmacovigilance study of the <scp>Food and Drug Administration Adverse Event Reporting System<\/scp>"],"prefix":"10.1111","volume":"89","author":[{"given":"Haixia","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pharmacy Second Affiliated Hospital and Yuying Children's hospital of Wenzhou Medical University  Wenzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-976X","authenticated-orcid":false,"given":"Dawei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy 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