{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:05:40Z","timestamp":1781085940697,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Stevens\u2010Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life\u2010threatening and rare severe cutaneous adverse reactions induced by drugs in most cases. The drugs most often reported to be implicated in inducing TEN\/SJS are allopurinol, antibacterial sulfonamides, antiepileptic drugs and oxicam. Pristinamycin is an oral streptogramin antibiotic with bactericidal activity against Gram\u2010positive bacteria that is rarely linked to TEN. Typically, this condition develops 4\u201028\u2009days after drug exposure, Herein, we report a case of a 71\u2010year\u2010old female who developed TEN within 3\u2009days of administration of pristinamycin and was managed successfully with supportive care, including intravenous fluids, pain control, prophylactic antibiotics and intravenous methylprednisolone. This case of rapidly developing SJS\/TEN after administration of pristinamycin highlights the possibility that these complications can develop within only a few days following ingestion of drugs thought to be probably safe.<\/jats:p>","DOI":"10.1111\/bcp.15600","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T14:14:30Z","timestamp":1668694470000},"page":"1869-1872","source":"Crossref","is-referenced-by-count":3,"title":["Pristinamycin\u2010induced toxic epidermal necrolysis: A case report"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-1748","authenticated-orcid":false,"given":"Bouraoui","family":"Ouni","sequence":"first","affiliation":[{"name":"Laboratoire de Biophysique M\u00e9tabolique et Pharmacologie Appliqu\u00e9e (LR 12ES02), Facult\u00e9 de M\u00e9decine de Sousse Universit\u00e9 de Sousse  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-1102","authenticated-orcid":false,"given":"Khadija","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Fatouma Bourguiba University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoudha","family":"Slim","sequence":"additional","affiliation":[{"name":"Laboratoire de Biophysique M\u00e9tabolique et Pharmacologie Appliqu\u00e9e (LR 12ES02), Facult\u00e9 de M\u00e9decine de Sousse Universit\u00e9 de Sousse  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihed","family":"Abdessayed","sequence":"additional","affiliation":[{"name":"Department of Anatomopathology Farhat Hached hospital  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Bensayed","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Farhat Hached Hospital  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Barka","sequence":"additional","affiliation":[{"name":"Department of Surgery Farhat Hached University Hospital of Sousse  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neila","family":"Fathallah","sequence":"additional","affiliation":[{"name":"Laboratoire de Biophysique M\u00e9tabolique et Pharmacologie Appliqu\u00e9e (LR 12ES02), Facult\u00e9 de M\u00e9decine de Sousse Universit\u00e9 de Sousse  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.510"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.252"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.06.213"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2004.00280.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2000.00061.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S142226"},{"key":"e_1_2_10_8_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 \u2010 PYOSTACINE (pristinamycine) [Internet]. [cited 2022 Jun 27].https:\/\/www.has-sante.fr\/jcms\/c_1332090\/fr\/pyostacine-pristinamycine"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv457"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg143"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki108"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20106576.2005.00685.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2014.4.1.68"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2016.6.1.70"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:53:22Z","timestamp":1722333202000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/bcp.15600"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15600","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}