{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:08:10Z","timestamp":1793164090807,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173897"],"award-info":[{"award-number":["82173897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Ceftriaxone is widely used in children with community\u2010acquired pneumonia. Currently, there are no available data regarding epithelial lining fluid (ELF) concentrations of ceftriaxone in children. Thus, blood and bronchoalveolar lavage fluids samples were collected by using an opportunistic sampling design, then we determined plasma and ELF concentrations in 22 children (0.5\u201311.7\u2009years), with a total of 36 plasma and 22 ELF samples available for analysis. Ceftriaxone plasma and ELF concentrations ranged from 1.07 to 138.71\u2009mg\/L and from 0.61 to 26.69\u2009mg\/L, respectively. Ceftriaxone concentration in ELF was 12.18\u2009\u00b1\u20095.15 (mean \u00b1 standard deviation) times higher than that in plasma, ranging from 1.29 to 20.44.<\/jats:p>","DOI":"10.1111\/bcp.15616","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T11:59:10Z","timestamp":1669636750000},"page":"1491-1494","source":"Crossref","is-referenced-by-count":8,"title":["Epithelial lining fluid concentrations of ceftriaxone in children with community\u2010acquired pneumonia"],"prefix":"10.1111","volume":"89","author":[{"given":"Yi\u2010Ning","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Pharmacy, Shandong Provincial Third Hospital Shandong University  Jinan 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Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"van den Anker","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Children's National Hospital  Washington District of Columbia USA"},{"name":"Departments of Pediatrics, Pharmacology &amp; Physiology, Genomics and Precision Medicine, School of Medicine and Health Sciences George Washington University  Washington District of Columbia USA"},{"name":"Department of Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel University of Basel  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Xiang","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University  Jinan 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