{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:28:22Z","timestamp":1785767302469,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/18\/4\/34215"],"award-info":[{"award-number":["RE\/18\/4\/34215"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","award":["COVID 19 Research Fund"],"award-info":[{"award-number":["COVID 19 Research Fund"]}],"id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>COVID\u201019 causes significant thrombosis and coagulopathy, with elevated D\u2010dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear; one hypothesis is that loss of angiotensin\u2010converting enzyme 2 activity during viral endocytosis leads to pro\u2010inflammatory angiotensin\u2010II accumulation, loss of angiotensin\u20101\u20107 and subsequent vascular endothelial activation. We undertook a double\u2010blind randomized, placebo\u2010controlled experimental medicine study to assess the effect of TRV027, a synthetic angiotensin\u20101\u20107 analogue on D\u2010dimer in 30 patients admitted to hospital with COVID\u201019. The study showed a similar rate of adverse events in TRV027 and control groups. There was a numerical decrease in D\u2010dimer in the TRV027 group and increase in D\u2010dimer in the placebo group; however, this did not reach statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u2009.15). A Bayesian analysis demonstrated that there was a 92% probability that this change represented a true drug effect.<\/jats:p>","DOI":"10.1111\/bcp.15618","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:27:42Z","timestamp":1669620462000},"page":"1495-1501","source":"Crossref","is-referenced-by-count":6,"title":["The effect of TRV027 on coagulation in COVID\u201019: A pilot randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-5802","authenticated-orcid":false,"given":"Alexander J.","family":"Robbins","sequence":"first","affiliation":[{"name":"Imperial College Research Facility Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Amalina","family":"Che Bakri","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Toke\u2010Bjolgerud","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Edwards","sequence":"additional","affiliation":[{"name":"Imperial College Research Facility Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Vikraman","sequence":"additional","affiliation":[{"name":"Imperial College Research Facility Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Michalsky","sequence":"additional","affiliation":[{"name":"Trevena, Inc.  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